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Expert prediction

Cardinals vs Cowboys Prediction: Dallas Should Feast on the NFL’s Worst Defense

  • Nikola Velickovic
  • Oct 27, 2026 at 11:45 AM EDT

Pick rationale

Analysis & key factors

Best bet: Cowboys -6

Straight-up pick: Cowboys (-285)

Total pick: Over 54.5

Bet Cardinals vs Cowboys at BetUS

The Cowboys are finally back home after a long stretch on the road, and a win over the struggling Cardinals would get them back to .500. Arizona comes in with the worst defense in the NFL, allowing 29.7 points per game.

You can see all of our NFL picks for Week 8, but here’s why I’m backing Dallas to cover at home, and how you can bet on Cardinals vs Cowboys.

Sunday, Nov 1 · 1:00 PM ET · AT&T Stadium · FOX

Cardinals vs Cowboys Betting Odds (BetUS)

TeamMoneylineSpreadTotals
Cardinals+230+654.5
Cowboys-285-654.5

Game Preview

Arizona Cardinals

Arizona got a reality check in Week 7, losing 30-16 at home to the Broncos just a week after a road win over the Rams. It was the Cardinals’ fifth loss of the season, and the defense remains the biggest problem, allowing a league-worst 29.7 points per game.

Head coach Mike LaFleur and defensive coordinator Nick Rallis have plenty to fix. The pass rush is generating little pressure, and the red-zone defense has been even worse, giving up touchdowns on 17 of 24 trips inside the 20.

Dallas Cowboys

Dallas went into Philadelphia and came away with a 38-21 win, easily covering the spread against an Eagles team missing several key players.

Dak Prescott threw for 212 yards and three touchdowns, while RB Javonte Williams ran for 155 yards and a score on 25 carries. Williams now has eight rushing touchdowns on the season, and the special teams chipped in with 92 punt return yards. That’s a lot of ways to score against a defense that struggles to get off the field.

Cardinals vs Cowboys Predictions

Dallas has already slipped up once at home this season, against Tampa Bay, and with a playoff spot in the balance, it can’t afford another. Confidence is high after a statement win in Philadelphia, and the matchup could hardly be better against the league’s worst scoring defense.

At -285, the moneyline is a short price, so the value is on the spread. Williams and the Dallas run game should control this one, and with Arizona allowing touchdowns on more than 70% of its red-zone trips, the Cowboys have every chance of winning by a touchdown or more.

With the Cardinals giving up nearly 30 points a game and Dallas coming off 38 in Philadelphia, the Cowboys can do most of the work on their own, and even a modest day from the Arizona offense should push this past 54.5.

  • Best bet: Cowboys -6
  • Cardinals vs Cowboys straight-up pick: Cowboys (-285)
  • Cardinals vs Cowboys over/under pick: Over 54.5

How to Bet on Cardinals vs Cowboys

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