Expert prediction
Jacksonville Jaguars vs Indianapolis Colts Odds, and Picks (Sep 10)
- Keith McCarthy
- Aug 30, 2023 at 8:11 PM EDT
Pick rationale
Analysis & key factors
- Jacksonville went 9-8 last season, and won a weak AFC South division.
- The Colts had a very rough showing, posting a final record of 4-12-1.
- These two teams last met on October 16, in a game the Colts won 34-27.
The NFL season kicks off next week. Let’s preview the upcoming Jaguars vs Colts AFC South clash. Jacksonville is heavily favored to repeat as division champions, while the Colts start a new era at QB.
How to Watch
- FOX
Preview
The Jaguars took a big step forward last year in QB Trevor Lawrence’s 2nd season. With the Urban Meyer days behind them, Jacksonville and Lawrence will now benefit from being in the same system for two years in a row. Between their continued improvement, and a very weak AFC South division, the Jaguars may be one of the safest preseason bets to make the playoffs. They need to avoid a surprise upset here.

Indianapolis named rookie QB Anthony Richardson as their starter, officially starting a new era. After fielding Jacoby Brissett, Brian Hoyer, Phillip Rivers, Carson Wentz, Matt Ryan, Nick Foles, and Sam Ehlinger at the QB spot in the 4 seasons since Andrew Luck last took the field, the Colts should finally have their QB of the future. It make take time for Richardson to acclimate to the NFL level, but Indy’s future is bright.
Prediction
With an inexperienced Richardson getting his first NFL start, and RB Jonathan Taylor on the PUP list, it’s hard to imagine the Colts producing much on offense in this game. That being said, they did score 34 points in their last matchup against Jacksonville, so it can’t be totally ruled out. Unless Richardson comes out playing like a superstar in Week 1, the Jaguars should get a pretty easy road victory to start their year.
NFL Picks:
- Jaguars 27, Colts 16 ()
Market
Odds currently unavailable
No odds are available for this selection yet.
NFL
More Predictions
NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread
Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]
NNikola Velickovic 3 min read
NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow
NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]
NNikola Velickovic 2 min read
Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina
Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]
NNikola Velickovic 2 min read
Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly
Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]
NNikola Velickovic 2 min read
Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland
Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]
NNikola Velickovic 2 min read