Expert prediction
NFL Week 6: 49ers vs. Seahawks Preview, Odds, Lines, Predictions, Pick
Pick rationale
Analysis & key factors
- 49ers vs. Seahawks matchup features NFL Week 6 Thursday Night Football.
- The two NFC West division rivals both lost their previous games.
- Christian McCaffrey is probably out for this one.
Both the Niners and the Seahawks struggle at the moment. San Francisco is 2-3 after five games, while Seattle has three wins and two losses. However, the team from the state of Washington comes into this one following back-to-back defeats.
Wizards vs. Knicks NBA Preseason Preview and Pick
How to Watch:
- Where: Lumen Field, Seattle, Washington
- When: Thursday, October 10, 8:15 pm ET
- How to Watch: Prime Video
49ers vs. Seahawks Odds & Lines
| Team | Odds | Spread | Totals |
|---|---|---|---|
| 49ers | -165 | -3.5 | 47.5 |
| Seahawks | +140 | +3.5 | 47.5 |
49ers vs. Seahawks Preview
San Francisco lost to another NFC West rival this Sunday when the Cardinals flew back to Arizona with a 24-23 win. It was a shocker at Levi’s Stadium, particularly because the Niners couldn’t score a single point in the final 12 minutes, allowing the rivals to snatch a big-time victory.
Brock Purdy was picked twice. The young QB also had one touchdown toss and 244 passing yards. Meanwhile, Jordan Mason had 89 yards on the ground with a lost fumble, while Brandon Aiyuk scored 147 receiving yards.
Seattle lost to the Giants at Lumen Field, 29-20. Their third down conversion (3-for-11) was the main reason Daniel Jones and his boys left the stadium with a W. The second one was that QB Geno Smith had 72 rushing yards, and the rest of the team had 30. That’s terrible.
DK Metcalf fumbled the ball again after a turnover against the Lions the week before. The Seahawks defense was solid, with Rayshawn Jenkins even scoring a TD, but it wasn’t there when needed the most.
49ers vs. Seahawks Head to Head
As division rivals, these teams meet often. Last year, the 49ers won both events: 31-13 in Seattle and 28-16 at home.
49ers vs. Seahawks Predictions
This one is a must for the Niners, despite them playing on the road. A break is necessary following the home loss, and this is a good chance. The Seahawks are declining, which was expected because their opening rivals weren’t that strong. Their honeymoon is over, and the 49ers will prove that.
- Thursday Night Football Picks: 49ers -3.5
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