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Expert prediction

NFC West Winner 2025 Outright Odds, Preview, Predictions

  • Nikola Velickovic
  • Jul 16, 2025 at 4:42 AM EDT

Pick rationale

Analysis & key factors

  • NFC West title favorites are the 49ers and the Rams.
  • Kyler Murray and Marvin Harrison Jr. could form an unstoppable duo.
  • Sam Darnold now leads the Seattle Seahawks.

NFC West will be very interesting to watch this year, as there are two big favorites for winning the divisional title and two teams waiting for their chance to jump out. To be honest, it wouldn’t be strange to see either of the four teams clinch the division.

Check out more of our Divisional Previews.

NFC West Odds

TeamOdds
49ers+150
Rams+175
Cardinals+450
Seahawks+550

NFC West Preview

San Francisco 49ers

The biggest question for Kyle Shanahan and his team concerns their health. If the 49ers have luck and their top players stay out of the injury list, they can not only win the division but also go deep into the playoffs. The x-factor for the Nines could easily be WR Ricky Pearsall, who missed a huge part of last season. Also, Robert Saleh is back as DC.

LA Rams

Right out of nowhere, the Rams have a great team again. Many believe they’ll collapse after Aaron Donald’s departure, yet that didn’t happen. Now, Davante Adams landed in LA, which will be hugeeee for Matt Stafford, while Puka Nacirema and Kyren Williams wait to pick up where they left off last year. And defense, with Rookie of the Year, Jared Verse and the likes of Fiske, Turner, and Young has a lot to offer.

Arizona Cardinals

If Murray and Marvin Harrison Jr. continue to evolve, they could be the next best thing in the NFL. And if James Conner remains stable, there you have one of the best offenses in the conference. The defense is an enigma, as it could be very good, but mediocre too. There’s talent, and now it’s all up to Nick Rallis to blend them into a formidable unit. After all, they spent five of their first picks on defenders.

Seattle Seahawks

Sam Darnold is in Seattle. So, that’s already causing mixed reactions. DK Metcalff is out. That’s negative. Yet, the defense is among the best in the league, and we’ll see who all this turns out. The Seahawks might reach the playoffs, but their chances of winning the NFC West are far slimmer.

NFC West Predictions

Our pick here would be the Rams, who are forming once again a Super Bowl-worthy team. Even though our words don’t sound too logical now, believe us when we say that the LA team is the strongest in this group.

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