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Expert prediction

NFL Week 2: Giants vs. Cowboys Preview, Odds, Picks (Sep 14)

  • Nikola Velickovic
  • Sep 9, 2025 at 7:27 AM EDT

Pick rationale

Analysis & key factors

  • Giants vs. Cowboys odds favor Dallas at -240.
  • New York Giants had just 74 rushing yards against the Commanders.
  • The Dallas Cowboys lost to the Super Bowl Champions, the Eagles, 24-20.

This is perhaps the flashiest rivalry in the NFL, featuring two powerhouses. The Cowboys are favorites, with the spread they need to cover set at 3.5 points.

If you are want more NFL odds and predictions, follow this link.

How to Watch

  • When: Sunday, September 14, 1 pm ET
  • Where: AT&T Stadium, Arlington, Texas
  • How to Watch: FOX

Giants vs. Cowboys Odds

TeamMoneylineSpreadTotals
Giants+215+5.544.5
Cowboys-240-5.544.5

Game Preview

Apart from Graham Gano’s two field goals, the Giants were scoreless in DC against the Commanders. That game ended 21-6 for the hosts, who demolished the opponents with their running. Giants had 74 yards on the ground in 23 attempts, while on the other hand, the Commanders had 220 in nine more.

Russell Wilson had 168 passing yards, though he completed only 17 of his 37 attempts. DangeRuss had 44 rushing yards too, the most in New York. Other rushers combined for a sorry 33 yards.

The Cowboys were pretty close to an upset in Philly. For more than 23 minutes, we saw no points on both sides, and Dak Prescott couldn’t find a way to hurt the rivals and find the end zone.

Prescott ended the night with 188 passing yards, no touchdown passes, interceptions, fumbles, or sacks. WR CeeDee Lamb had 110 receiving yards on 7 catches, but apart from him, the guests didn’t have anyone to contribute.

Giants vs. Cowboys Head to Head

Dallas Cowboys lead the all-time series 77-47-2. They have 8 straight wins against the Giants and 15 in the last 16 events.

Giants vs. Cowboys Predictions

Giants are among the weakest teams in the NFC, and for sure the weakest in the NFC East. The Cowboys should win this event, despite the recent Micah Parsons trade. We are backing up the Cowboys to cover the spread.

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