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Expert prediction

NFL Week 2: Panthers vs. Cardinals Preview, Odds, Picks (Sep 14)

  • Nikola Velickovic
  • Sep 9, 2025 at 11:24 AM EDT

Pick rationale

Analysis & key factors

  • Panthers vs. Cardinals spread favors Arizona by 6.5 points.
  • Carolina Panthers failed to record a sack against the Jaguars.
  • Cardinals beat the Saints on the road, 20-13.

The Arizona Cardinals are after a 2-0 start since 2021. And they have just the right rival for that—the sorry Carolina Panthers.

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How to Watch

  • When: Sunday, September 14, 4:05 pm ET
  • Where: State Farm Stadium, Glendale, Arizona
  • How to Watch: CBS

Panthers vs. Cardinals Odds

TeamMoneylineSpreadTotals
Panhters+240+6.545.5
Cardinals-290-6.545.5

Game Preview

Carolina Panthers lost to the Jaguars on the road, 26-10. Believe it or not, they didn’t record a single sack in this event. That’s the first thing we noticed when looking at their defense. And we can’t say that Jacksonville has an incredibly strong offensive line.

Bryce Young once again gave his critics ammunition, as he passed for 154 yards, posting a touchdown but adding two interceptions and one lost fumble. As time passes, it becomes increasingly clear that this individual cannot be a starter in the NFL.

On the other hand, another former No.1 pick, Kyler Murray, proves the opposite. He had 163 passing yards for two touchdown passes and ran for 38 more. However, the Saints did sack Murray 5 times.

We have to note that the Cardinals ran the ball well, racking up 146 yards on the ground on 27 carries. Trey Benson had 69 and James Conner 39. Conner caught a pass for a touchdown, the same as Marvin Harrison Jr.

Panthers vs. Cardinals Head to Head

There haven’t been too many games between these two franchises, just 21. The record at the moment is 15-6 for Carolina.

Panthers vs. Cardinals Predictions

Panthers are easy prey for Arizona, who should win this match and also cover a 6.5 spread.

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