MLS: Inter Miami vs. Seattle Sounders Picks, Odds, and Preview (Sep 16)

The pressure will be on Lionel Messi and his Inter Miami side this week, as they clash with the Seattle Sounders in a rematch of the 2025 Leagues Cup final. Miami have suffered defeats in their last two matches across all competitions, and suddenly look vulnerable in the race to secure a playoff spot.

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How To Watch

• When: Tuesday, September 16, 2025, at 7:30 PM ET
• Where: Chase Stadium, Miami
• How To Watch: Apple TV

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Inter Miami vs. Seattle Sounders Odds

Match Result	Odds
Inter Miami	-102
The Draw	+292
Seattle Sounders	+264

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Head-to-Head Record

The Seattle Sounders will take confidence from the latest meeting between the sides after recording a 3-0 win in the Leagues Cup final earlier this month.

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Match Preview

The pressure will be on Inter Miami, as the end of the regular season creeps ever nearer. Messi’s side comes into this round of matches sitting eighth in the Eastern Conference standings, and a return to form will be required following a second straight 3-0 defeat against Charlotte last weekend.

There is no denying that Inter are one of the best offensive sides in the MLS, as they have averaged 2.08 goals per game this season. However, defensively, there are huge questions to answer. Miami have allowed 1.65 efforts per game, and have kept clean sheets in just 15% of their matches.

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The Seattle Sounders could be just a few wins away from securing their spot in the post-season. They have won 12 of their 28 matches this season, and only four teams in the Western Conference have scored more goals than the Sounders in 2025.

However, they will need to respond after throwing away a 2-0 lead in their recent clash with the LA Galaxy. Despite dominating that clash, they allowed the Galaxy to snatch a point in the closing stages. But, their offensive quality looks set to cause Inter a lot of issues this week.

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Inter Miami vs. Seattle Sounders Picks

Inter Miami have hit a lull in their form across recent weeks, and that would be a major concern at this late stage of the campaign. The Sounders look too big of a price to ignore in the betting this week, especially considering their recent win against Miami.

Free Picks:

• Seattle Sounders (+264)