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Expert prediction

NFL Week 3: Rams vs. Eagles Preview, Odds, Picks (Sep 21)

  • Nikola Velickovic
  • Sep 16, 2025 at 5:12 PM EDT

Pick rationale

Analysis & key factors

  • Rams vs. Eagles total is set at 44.5 points.
  • Both teams are 2-0.
  • Eagles have won 9 of the last 10 games against the Rams.

An NFC big-time clash takes place this Sunday in Philly, with the Super Bowl champions, the Eagles, hosting the Rams.

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How to Watch

  • When: Sunday, September 21, 1 pm ET
  • Where: Lincoln Financial Field, Philadelphia, Pennsylvania
  • How to Watch: FOX

Rams vs. Eagles Odds

TeamMoneylineSpreadTotals
Rams +160+3.543.5
Eagles-190-3.54.5

Game Preview

The Rams blew away the Titans in Nashville, 33-19, after a bit of a slow opening half that saw the struggle on both ends of the field. As soon as the second half started, it was all about them.

Matt Stafford had 298 passing yards for two TDs and an interception, and was sacked just once. WR Davante Adams posted 106 receiving yards in 6 catches and a TD, while Puka Nacua had 91 yards. LB Byron Young had two sacks.

The Eagles squeaked a win on the road in Kansas City, beating the Chiefs, 20-17. The Super Bowl replay showcased a tremendous defensive effort by the champions, who effectively contained Mahomes and the Chiefs in the second half.

Though, we have to admit that the Eagles had their share of struggles in offense. Hurts passed for just 101 yards, and if it weren’t for RB Saquon Barkley, who ran 88 yards for a TD, this one would end differently.

Rams vs. Eagles Head to Head

The Rams have lost 9 of the last 10 against the Eagles. The most recent was in the NFC Divisional Game this January, when Philly triumphed 28-22.

Rams vs. Eagles Predictions

This will be a hard one, because the Rams have enough quality to challenge the Eagles in their own house. Now, given the fact that the champs aren’t playing as well as the results show, we go with the Rams to cover an alternative handicap of 6.5 points.

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