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Expert prediction

NFL Week 3: Texans vs. Jaguars Preview, Odds, Picks (Sep 21)

  • Nikola Velickovic
  • Sep 16, 2025 at 5:13 PM EDT

Pick rationale

Analysis & key factors

  • Texans vs. Jaguars game is a must-win for both sides.
  • The Houston Texans are 0-2.
  • Jaguars couldn’t beat Bengals without Burrow last Sunday.

Tension is pretty high in Houston, and to be honest, this game can seal the fate of DeMeco Ryans as the Texans’ head coach.

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How to Watch

  • When: Sunday, September 21, 1 pm ET
  • Where: EverBank Stadium, Jacksonville, Florida
  • How to Watch: CBS

Texans vs. Jaguars Odds

TeamMoneylineSpreadTotals
Texans-105+1.544.5
Jaguars-115-1.544.5

Game Preview

Texans QB CJ Stroud expressed his frustration with the way things are going. The pressure is high on him and the head coach, DeMeco Ryans, who now has to win this one; otherwise, the AFC South is in jeopardy of being lost.

Both of Houston’s losses were tight, 14-9 on the road vs. the Chargers and 20-19 at home to Tampa Bay. The defense is solid, but the offense isn’t at the usual level. Stroud has just one passing TD so far.

The Jaguars had a chance to beat the Bengals, but wasted it because they couldn’t utilize the three turnovers the second-string QB Jake Browning handed them. It was 31-27 for Cinci, and a bitter hit in the mouth for the Jags.

Lawrence was mediocre again, having 271 passing yards, 3 touchdowns, but 2 interceptions. He also fumbled once, but luckily that ball was recovered. If he doesn’t step up soon, and the Jags miss another playoff, who knows what can happen during the offseason.

Texans vs. Jaguars Head to Head

After 46 games, the result is 31-15 for the Texans. Last season, Houston was better on both occasions, 24-20 at home and 23-20 on the road.

Texans vs. Jaguars Predictions

The Texans’ defense is very strong, and because of that, we are betting on the guests to win this one and get away from Florida with a victory. The Jags aren’t confident at all, and we have to go with the Texans.

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