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Expert prediction

NFL Week 3: Steelers vs. Patriots Preview, Odds, Picks (Sep 21)

  • Nikola Velickovic
  • Sep 16, 2025 at 6:20 PM EDT

Pick rationale

Analysis & key factors

  • Steelers vs. Patriots used to be a huge rivalry between the 90s and the 2010s.
  • The Steelers are 1.5-point favorites in this one.
  • Both teams are 1-1 ahead of Sunday’s game.

When Roethlisberger and Brady dominated the league, this matchup was the biggest one possible in the NFL. Even though times have changed, many still love to see these two AFC powerhouses clash.

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How to Watch

  • When: Sunday, September 21, 1 pm ET
  • Where: Gillette Stadium, Foxborough, Massachusetts
  • How to Watch: CBS

Steelers vs. Patriots Odds

TeamMoneylineSpreadTotals
Steelers-130-1.544.5
Patriots+110+1.544.5

Game Preview

When needed the most, the Steelers failed to show up, and we mean that. Losing 31-17 at home to the Seahawks is a huge blow, but what’s worse is that there wasn’t a bright spot in Pittsburgh’s offense.

Rodgers had been intercepted twice, the rushers combined for 72 yards only, and the defense provided just two sacks. On top of that, the Steelers’ offensive line really looked mediocre, which is problematic when you have a quarterback who is in his fifth decade.

Unlike them, the Patriots rose above the situation to beat the AFC East rivals, the Miami Dolphins, 33-27. New England made Tua Tagovailoa uncomfortable in the deciding moments, with the defense posting 5 sacks.

On the other hand, the running game provided 122 yards on the ground with one touchdown, while Drake Maye passed for 230 yards and two scores. By the way, Maye ran into the endzone once as well. Plus, the special team had a TD too. Overall, this was a good game for Mike Vrabel and his team.

Steelers vs. Patriots Head to Head

The Pittsburgh Steelers have lost to the New England Patriots in 8 of the last 9 meetings.

Steelers vs. Patriots Predictions

The Steelers have problems in their game, which was visible against the Jets, too, despite the win. Pats oscillate, yet they have a good defense; that’s something noticeable. Our pick for this one will be Under 44.5 points, because both teams have tough defensive teams, plus, both Vrabel and Tomlin know to enter that ’90s old school mode where they focus on stopping the rivals.

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