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Expert prediction

NFL Week 3: Saints vs. Seahawks Preview, Odds, Picks (Sep 21)

  • Nikola Velickovic
  • Sep 17, 2025 at 5:22 AM EDT

Pick rationale

Analysis & key factors

  • Saints vs. Seahawks game total is 41.5 points.
  • The Seattle Seahawks defeated the Steelers on the road, 31-17.
  • Saints won the previous four events against the Seahawks.

Spencer Rattler will have to do much better. His Saints are 0-2, and even though he’s still adjusting to the NFL, the frustration of him not getting the first win as a starter is growing.

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How to Watch

  • When: Sunday, September 21, 4:05 pm ET
  • Where: Lumen Field, Seattle, Washington
  • How to Watch: CBS

Saints vs. Seahawks Odds

TeamMoneylineSpreadTotals
Saints +300+7.541.5
Seahawks-400-40041.5

Game Preview

For the moment, Spencer Rattler is 0-8 as the Saints starter. That’s what frustrates every New Orleans fan, and believe us when we say, it’s just a matter of time before he gets criticized in public, getting even more pressure to handle.

Overall, he isn’t that bad, 421 passing yards for 3 touchdowns and no picks in the opening two events. But the Saints are losing, and that’s all that matters. DE Chase Young is questionable for this one, but is expected to play.

The Seahawks rolled over the Steelers at Acrisure, beating Rodgers and the boys 31-17. Sam Darnold alone had more passing yards – 295, than the whole Steelers’ team generated from the scrimmage, 275. Darnold threw for two touchdowns and picks.

Kenneth Walker III ran for 105 yards and a touchdown, while the run defense did its job perfectly, as the entire Pittsburgh team had only 72 yards on the ground.

Saints vs. Seahawks Head to Head

The result in the series is 10-8 for the Saints, who won the previous 4 meetings with the Seahawks.

Saints vs. Seahawks Predictions

This is a nice chance for the Seahawks to capitalize on the win in Pittsburgh, as they have arguably the weakest team in the NFC coming to town.

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