Expert prediction
Premier League: Man United vs. Chelsea Picks, Odds, and Preview (Sep 20)
- Alex Dudley
- Sep 17, 2025 at 6:00 AM EDT
Pick rationale
Analysis & key factors
A heavyweight showdown is set for the Premier League on Saturday, as out-of-sorts Man United take on Chelsea. The pressure will be on Ruben Amorim following a dismal showing against Man City last Sunday, but can the Red Devils get back on track against the Blues? Find our picks here?
How To Watch
- When: Saturday, September 20, 2025, at 12:30 PM ET
- Where: Old Trafford, Manchester, England
- How To Watch: NBC
Man United vs. Chelsea Odds
Head-to-Head Record
Man United have avoided defeat in their last 12 Premier League home matches against Chelsea. Chelsea’s last away victory against the Red Devils was achieved back in May 2013.
Match Preview
Another new season brings with it another new crisis for Man United. Ruben Amorim’s side had performed well in their opening three league matches, but a sign that things may not have improved at all was evident in last weekend’s 3-0 defeat against Man City.
However, confidence can still be taken from the fact that United have the second-best xG in the EPL this season, but it should also be noted that only three teams have a worse xGA. But, the Red Devils have recorded victories in two of their last three home matches, which is as many victories as they had recorded at Old Trafford in their previous eleven.
READ More: USA Today 301 Picks, Odds, and Preview (Sep 21)
Chelsea’s title credentials failed to pass the Brentford test last weekend, as the Blues allowed a 2-1 advantage to slip in the closing stages. Former United player Alejandro Garnacho lost his man in the final minute of injury time, which ensured that the Blues dropped points for the second time in four matches.
Despite that, Chelsea are still unbeaten in the Premier League this season. They will also take confidence from the fact that they recorded a 1-0 win over United in the previous encounter between the sides. However, Chelsea haven’t recorded back-to-back wins against the Red Devils since March 2011.
Man United vs. Chelsea Picks
This is a fascinating Premier League clash, and there will be huge pressure on Amorim and his United side. However, it could be worth noting that Man United vs. Chelsea is the most drawn fixture in EPL history. In fact, seven of the last 12 at Old Trafford have ended level. That could pinpoint the most interesting betting angle on Saturday.
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