Skip to content

Expert prediction

NFL Week 4: Seahawks vs. Cardinals Preview, Odds, Picks (Sep 25)

  • Nikola Velickovic
  • Sep 22, 2025 at 8:13 AM EDT

Pick rationale

Analysis & key factors

  • Seahawks vs. Cardinals TNF moneyline is even.
  • Cardinals RB James Conner is out for the season due to an ankle injury.
  • The Seattle Seahawks have won the last 7 games against the Cardinals.

The NFC West will be electric this year, because all 4 teams attack the NFL playoffs. As a divisional rivalry, this matchup will have a huge impact on the final standings.

If you want more NFL odds and predictions, please follow this link.

How to Watch

  • When: Thursday, September 25, 8:15 pm ET
  • Where: State Farm Stadium, Glendale, Arizona
  • How to Watch: Prime Video

Seahawks vs. Cardinals Odds

TeamMoneylineSpreadTotals
Seahawks-110EVEN43.5
Cardinals-110EVEN43.5

Game Preview

Seattle’s offense had a light practice against the Saints this Sunday afternoon, winning this event 44-13. WR Tory Horton made a play of the game when he returned the punt all the way to the endzone, for 95 yards. He had one more receiving TD later, ending the game with 114 returning yards and 32 receiving.

Kenneth Walker III rushed for two scores, while Sam Darnold threw 218 yards for 2 TD passes, completing 14 of his 18 pass attempts.

The Cardinals have not just suffered a defeat to the Niners (16-15) via field goal as time expired, but they also lost James Conner for the rest of the season. The strong running back injured his ankle, and this is a massive blow for the Cards.

What does this mean for all the NFL bettors? First, the backup RB, Trey Benson, will have to step up. Secondly, we expect to see Murray running even more than before. Keep this in mind when making some NFL prop bets or anything similar.

Seahawks vs. Cardinals Head to Head

The overall record is on Seattle’s side, 29-22-1. Also, the Seahawks have 7 wins in a row. Last year, they were better at Lumen Field, 16-6, and in Arizona, 30-18.

Seahawks vs. Cardinals Predictions

It’ll be tough for the Cards to balance their game without Conner, particularly against the Seahawks’ defense, which has been solid so far. We will be risky here and go with Seattle to triumph.

Topics:

NFL

More Predictions

NFL Insight

NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread

Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]

Nikola Velickovic 3 min read

NFL Insight

NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow

NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]

Nikola Velickovic 2 min read

NFL Insight

Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina

Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]

Nikola Velickovic 2 min read

NFL Insight

Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly

Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]

Nikola Velickovic 2 min read

NFL Insight

Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland

Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]

Nikola Velickovic 2 min read