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Expert prediction

NFL Week 4: Packers vs. Cowboys Preview, Odds, Picks (Sep 28)

  • Nikola Velickovic
  • Sep 24, 2025 at 5:17 AM EDT

Pick rationale

Analysis & key factors

  • Packers vs. Cowboys is Week 4 Sunday Night Football.
  • Green Bay Packers are -300 favorites.
  • The Cowboys are 6.5-point underdogs.

Throughout history, we’ve seen so many spectacular games between these two franchises. That’s why the league decided to put this event in prime time.

If you want more NFL odds and predictions, please follow this link.

How to Watch

  • When: Sunday, September 28, 8:20 pm ET
  • Where: AT&T Stadium, Arlington, Texas
  • How to Watch: CBS

Packers vs. Cowboys Odds

TeamMoneylineSpreadTotals
Packers-300-6.547.5
Cowboys+250+6.547.5

Game Preview

Jordan Love isn’t an elite QB. We’ve mentioned that before, and against the Browns, we’ve seen why. He can’t handle the pressure, and to be honest, he had plenty of luck in the opening two events when some of his errors weren’t punished.

Yet the Packers’ defense is elite. Although they ultimately failed to stop Flacco, they remain the top defensive unit in the league, allowing only 44 points through the first three rounds. LB Rashan Gary has 4.5 sacks and leads the league.

Meanwhile, the Cowboys aren’t only playing poorly but also struggling with numerous injuries. It is expected to see Lamb, Clark, and Diggs against the Packers, but they won’t be 100% ready.

Dak Prescott was sacked and intercepted twice each in a 31-14 loss to the Bears in Chicago. He threw for 251 yards and a touchdown, and so far has 800 passing yards with 3 touchdowns and 3 interceptions in total.

Packers vs. Cowboys Head to Head

The Packers won 11 of the last 12 games against Dallas. In 2024, the Green Bay Packers beat the Cowboys 48-32 in the NFC Wild Card game.

Packers vs. Cowboys Predictions

The Packers have a significantly better defense and a healthier offense than the Cowboys, which is the reason to bet on the franchise from Wisconsin.

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