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Expert prediction

NFL Week 5: Raiders vs. Colts Preview, Odds, Picks (Oct 5)

  • Nikola Velickovic
  • Sep 30, 2025 at 3:21 AM EDT

Pick rationale

Analysis & key factors

  • Raiders vs. Colts game total is 47.5 points.
  • The Indianapolis Colts have the most field goals made in the NFL, 13.
  • Raiders lost three games in a row.

Daniel Jones and the Colts had everything in their hands against the Rams, but one clumsy move made by Adonai Mitchell ruined everything.

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How to Watch

  • When: Sunday, October 5, 1 pm ET
  • Where: Lucas Oil Stadium, Indianapolis, Indiana
  • How to Watch: FOX

Raiders vs. Colts Odds

TeamMoneylineSpreadTotals
Raiders+240+6.547.5
Colts-290-6.547.5

Game Preview

The Las Vegas Raiders have shown multiple flaws over the last three weeks, and it’s no wonder they have posted consecutive losses. The last one was a narrow loss at home against the Bears, 25-24, which saw their field goal attempt for the win blocked.

Geno Smith is bad. He had three interceptions against the Bears with just 117 passing yards. So far this year, he has posted 6 TD passes and 7 interceptions. One bright spot is rookie RB Ashton Jeanty with 282 rushing yards.

Adonai Mitchell could have buried the Rams, but he decided to show off and turned out to be both hilarious and tragic at the same time. Because of him, the Colts lost in LA 27-20.

Daniel Jones was picked off twice; he had one TD pass and 262 passing yards. Jonathan Taylor recorded only 76 rushing yards on 17 carries. The Colts are still No.3 in yards per game, at 397.2.

Raiders vs. Colts Head to Head

This game will be the 23rd meeting between these two teams. For the moment, it’s 11 wins apiece for each side.

Raiders vs. Colts Predictions

The Colts should have an easy task here because it’s evident that the Raiders are on a downward slope. Plus, Smith is highly unreliable, and the difference between him and Jones is huge.

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