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Expert prediction

NFL Week 5: Giants vs. Saints Preview, Odds, Picks (Oct 5)

  • Nikola Velickovic
  • Sep 30, 2025 at 10:48 AM EDT
  • Giants vs. Saints game odds are almost even.
  • WR Malik Nabers tore his ACL and ended his season.
  • New Orleans Saints have the 3rd-worst defense in the NFL, 30.2 ppg allowed.

This is the battle between two of possibly the weakest teams in the NFC. The Saints lost all 4 events, while the Giants won the previous game, but the cost was very high.

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How to Watch

  • When: Sunday, October 5, 1 pm ET
  • Where: Caesars Superdome, New Orleans, Louisiana
  • How to Watch: CBS

Giants vs. Saints Odds

TeamMoneylineSpreadTotals
Giants+110+1.540.5
Saints-130-1.540.5

Game Preview

The New York Giants have defeated the LA Chargers, 21-18, but the cost was too high. WR Malik Nabers tore his ACL and will be out for the season. He is one of the best receivers in the NFL, and his absence will undoubtedly be a massive blow for Brian Daboll’s crew.

Rookie QB Jaxson Dart made his first start and was responsible for two touchdowns. He would throw a TD pass to Theo Johnson for one and run himself for the other. Dart posted 111 passing yards and 54 rushing.

The Saints allow 30.2 points per game, which is the 3rd most in the NFL. Apart from the opening game in which they lost to the 49ers 26-21, the following two defeats were by double-digit margins.

QB Spencer Rattler is still without a win in the NFL. He is now 0-10, and to be honest, that frustrates the fans a lot. He threw for 5 touchdowns and one interception this year, recording 765 passing yards, but had no positive impact on the team’s results.

Giants vs. Saints Head to Head

Giants have a slight edge in all-time series, winning 17 games against the Saints, one more than their rivals have.

Giants vs. Saints Predictions

The New York Giants will be without their biggest weapon (Malik Nabers), and as a result, we are pretty certain that the Saints’ prospects of winning this game are quite high. If the Saints don’t triumph now, when will they?

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