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Expert prediction

NFL Week 10: Arizona Cardinals vs. Seattle Seahawks Preview, Odds, Picks (Nov 9)

  • Nikola Velickovic
  • Nov 5, 2025 at 4:00 AM EST

Pick rationale

Analysis & key factors

  • Cardinals vs. Seahawks odds favor Seattle at -320.
  • Jacoby Brissett will start for the Cards instead of injured Kyler Murray.
  • The Seahawks sacked their rivals 27 times this year.

Seattle Seahawks await their division rivals, the Arizona Cardinals, this Sunday. Kyler Murray is out for the guests, with Brissett being his replacement. Just to remind, the Seahawks already beat Arizona this season, 23-20 in Week 4.

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How to Watch

  • When: Sunday, October 9, 4:05 pm ET
  • Where: Lumen Field, Seattle, Washington
  • How to Watch: CBS

Cardinals vs. Seahawks Odds

TeamMoneylineSpreadTotals
Cardinals+260+6.545.5
Seahakws-320-6.545.5

Game Preview

The Arizona Cardinals have been in a rollercoaster situation, and after 5 straight losses, they finally won a game. It was a Monday Night Football clash in Arlington, where the Cards beat the Cowboys, 27-17. Arizona’s defense did an amazing job forcing three turnovers, while Brissett and the guys didn’t commit a single one.

Brissett had 261 passing yards, two touchdown passes, and was sacked 5 times. Meanwhile, Emari Demeracado led the way with 70 rushing yards, while Marvin Harrison Jr. caught one receiving TD and racked 96 yards through the air.

Seattle demolished the Washington Commanders in DC, 38-14. Not only did they win that one, but they also hurt Jayden Daniels. Sam Darnold threw 4 TD passes and was picked once, but that didn’t matter. He ended the game with 330 passing yards. Also, he wasn’t sacked at all, and so far this year, the Seahawks have allowed just 9 sacks.

Tory Horton had two receiving TDs, Jasxon Smith-Njigba had 129 receiving yards, while Cosy White and Elijah Arroyo added a receiving TD each.

Cardinals vs. Seahawks Head to Head

After 53 games, Seattle leads the all-time series, 30-22-1. Currently, they have won 8 consecutive games against the Cards. Most recent in September this year, 23-20 on the road.

Cardinals vs. Seahawks Predictions

Brissett gave the Cards some spark, but that will likely fade against the Seahawks’ ruthless defense. We expect to see Seattle sealing the deal right away and covering a 6.5-point spread.

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