Expert prediction
NFL Week 12: New York Giants vs. Detroit Lions Preview, Odds, Picks (Nov 23)
- Nikola Velickovic
- Nov 17, 2025 at 7:04 AM EST
Pick rationale
Analysis & key factors
- Giants vs. Lions spread is 11.5 points.
- Jameis Winston starts for the New York Giants.
- Lions are 2-3 in the last 5 games.
The Lions can’t afford to lose any more games, as they risk losing the top spot in the NFC North. They host the banged-up Giants, who have a new head coach and are playing without any pressure.
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How to Watch
- When: Sunday, November 23, 1 pm ET
- Where: Ford Field, Detroit, Michigan
- How to Watch: FOX
Giants vs. Lions Odds
Game Preview
The Giants’ run defense is subpar, currently ranking as the third-worst in the league, allowing 149.9 yards on the ground. Along with injuries, it’s the primary reason why this team has suffered five consecutive defeats.
Against the Packers, the NYG had a chance to triumph, but in the end, it was 27-20 for Green Bay, because Jameis Winston couldn’t deliver, making some errors in moments when he shouldn’t. All three touchdowns the Giants had were via run, two by Singletary and one by Winston.
🚨🚨INSANE CALL🚨🚨
— MLFootball (@MLFootball) November 17, 2025
THE REFS CALL THIS A PASS INTERFERENCE ON #LIONS ROCK YA-SIN ON 3RD & LONG AND GIVES PHILLY THE WIN.
THIS SHOULD HAVE BEEN AN OFFENSIVE PASS INTERFERENCE.
ONE OF THE WORST CALLS EVER.
No game should ever end like this.
pic.twitter.com/QCuoChEXH5
As for the Lions, their offense was blown into pieces in Philadelphia, where the hosts triumphed 16-9 this Sunday night. Jared Goff had one touchdown and one intercepted pass, completing only 14 of his 37 passes.
On the other hand, the defense was solid, but in the end, they allowed a touchdown by Hurts, and couldn’t stop Philly’s run game. Eagles eventually had 148 rushing yards, which is way too much for a game like this. For instance, the Lions had just 74. Also, we have to add that the officials helped Eagles a lot in this event.
Giants vs. Lions Head to Head
After 47 games, the result in the series is 25-21-1 for the Lions. In the past five games, the Lions have triumphed four times. Most recent was in 2022, when they beat NYG in the Big Apple 31-18.
Giants vs. Lions Predictions
The Lions are 11.5-point favorites, and we aren’t going to mess with the spread. The Over/Under line is 49.5 points, and that’s definitely Over for us, with the addition that the Lions are going to win. That’s one interesting NFL combo bet.
- Free NFL Picks: Lions and Over 49.5 points
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