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Expert prediction

NFL Week 14: LA Rams vs. Arizona Cardinals Preview, Odds, Picks (Dec 7)

  • Nikola Velickovic
  • Dec 2, 2025 at 10:45 AM EST

Pick rationale

Analysis & key factors

  • Rams vs. Cardinals odds set Arizona as a +350 underdog.
  • The Rams allow the 2nd-fewest points per game, 17.5.
  • Jacoby Brissett has 13 TD passes and 4 picks so far with 2,188 passing yards.

This is an NFC West game between the team that’s after the top spot in the division and the conference and the team that’s outside the playoff picture.

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How to Watch

  • When: Sunday, December 7, 4:25 pm ET
  • Where: State Farm Stadium, Glendale, Arizona
  • How to Watch: FOX

Rams vs. Cardinals Odds

TeamMoneylineSpreadTotals
Rams-455-8.548.5
Cardinals +350+8.548.5

Game Preview

The Rams’ loss to the Panthers last weekend, 31-28, is a huge setback because they now have the same record as the Seahawks, while the 49ers sit half a game behind. Though, this team is fantastic, as it is balanced across all positions.

The top MVP candidate, Matt Stafford, has 32 TD passes with 4 picks, while the NFL’s leading receiving TD leader is Davante Adams with 14. Plus, there is Puka Nacua with 1,019 receiving yards, third-best in the league. Meanwhile, the defense allows 17.5 points per game, 2nd second-fewest in the NFL.

Cardinals benched Kyler Murray and now go with Jacoby Brissett as the starting QB. Brissett plays well, with 13 TD passes and 4 picks this year, but the team isn’t posting good results and is currently riding a 4-game losing streak.

Arizona lost the last two events by three points, vs. Jacksonville, 27-24 OT, and on the road in Tampa Bay, 20-17. They will be looking to disrupt the division rival’s plans and hurt their playoff ambitions here.

Rams vs. Cardinals Head to Head

The Los Angeles Rams lead the series 49-30-2.

Rams vs. Cardinals Predictions

Since Arizona doesn’t have a notable defense, it’s also pretty fragile; this will be a good opportunity for Stafford and the boys to bounce back following last week’s loss to Carolina. We pick the Rams to win and cover an 8.5-point spread.

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