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Expert prediction

NFL Week 15: Arizona Cardinals vs. Houston Texans Preview, Odds, Picks (Dec 14)

  • Nikola Velickovic
  • Dec 8, 2025 at 11:16 AM EST

Pick rationale

Analysis & key factors

  • Cardinals vs. Texans odds favor Houston at -550.
  • The Houston Texans have the No. 1 defense in the NFL, 16 ppg.
  • The TOTAL has gone OVER in 4 of Arizona’s last 5 games.

Houston Texans look darn good these days, and if they beat the Cardinals, they will stay in the race for the AFC South title.

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How to Watch

  • When: Sunday, December 14, 1 pm ET
  • Where: NRG Stadium, Houston, Texas
  • How to Watch: FOX

Cardinals vs. Texans Odds

TeamMoneylineSpreadTotals
Cardinals+410+9.542.5
Texans-550-9.542.5

Game Preview

The Arizona Cardinals have 5 straight defeats. However, this is quite logical, given that several of their best players (like Marvin Harrison Jr.) are out, and they moved on from Kyler Murray, allowing Jacoby Brissett to take his place. Though we have to say the Cards play better than expected on the road, going 6-1 ATS in those games.

Last weekend, we saw Arizona getting dismantled at home by the Rams, 45-17. Their offense has been struggling lately, not scoring more than 22 points in regular time in the last 5 events.

Texans beat the Chiefs in Kansas City, 20-10. Their defense once again showed what it’s all about, picking Mahomes three times and limiting the hosts to 274 total yards.

Meanwhile, Stroud was rational even though conservative, having 203 passing yards and completing only 15 of his 31 passing attempts for a touchdown. The rushers were a bit sloppy here with 82 yards in total, but they didn’t have to be better due to their defense.

Cardinals vs. Texans Head to Head

The two franchises have met 6 times, and the results are tied so far, with three wins each.

Cardinals vs. Texans Predictions

Texans will win here, and they will cover the spread. Their defense is too much for the Cards, who are in trouble and don’t have their entire team available.

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