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Expert prediction

NFL Week 15: Buffalo Bills vs. New England Patriots Preview, Odds, Picks (Dec 14)

  • Nikola Velickovic
  • Dec 8, 2025 at 11:15 AM EST

Pick rationale

Analysis & key factors

  • Bills vs. Patriots odds are even.
  • In 6 of Buffalo’s last 9 games, the total went UNDER.
  • New England leads the AFC Conference with an 11-2 record.

The Buffalo Bills have to win here, not just because they aim to overtake the Pats in the AFC East, but also because of their playoff situation.

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How to Watch

  • When: Sunday, December 14, 1 pm ET
  • Where: Gillette Stadium, Foxborough, Massachusetts
  • How to Watch: CBS

Bills vs. Patriots Odds

TeamMoneylineSpreadTotals
Bills-115-1.550.5
Patriots-105+1.550.5

Game Preview

The Bills had a magical finish to their game against the Bengals, scoring 21 straight points in less than five minutes, flipping the result against Burrow and the boys, and getting a win worth gold, 39-34. It was the third victory for the Bills in the past four games.

Josh Allen showed his MVP game, completing 21 of 28 passes for 251 passing yards and three TD throws. He also ran for 78 more yards and one score on the ground. The Bills’ run game was excellent, providing 183 yards.

The Patriots sliced the Giants on Week 13 Monday Night Football, 33-15. This was their 10th victory in a row, and undoubtedly, this team is in the best form in the entire NFL. The way the Pats play right now is at a championship level.

Even though their defense looks rock-solid, 5 of their last 7 contests have ended with the OVER. Drake Maye needs one statement game to get back in the MVP race, and this is the perfect opportunity. Plus, he had a week off to recover and prepare for the Bills.

Bills vs. Patriots Head to Head

The first game of the season was in Buffalo, and the Pats won that one, 23-20. Overall, there have been 132 meetings between AFC East teams, with the Pats winning 80, the Bills 51, and one ending in a tie.

Bills vs. Patriots Predictions

This game promises excitement. And points as well. With the way the Bills play right now (as well as the Pats) OVER is guaranteed, and that would be our pick in this event.

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