Expert prediction
NFL Week 17: Jacksonville Jaguars vs. Indianapolis Colts Preview, Odds, Picks (Dec 28)
Pick rationale
Analysis & key factors
- Jaguars vs. Colts odds favor Jacksonville at -300.
- The Colts have 5 defeats in a row.
- Jacksonville Jaguars have 6 straight triumphs.
Both of these AFC South rivals are in desperate need of a win – Jags to keep chasing the top spot in the conference, and the Colts to stay in the playoff picture.
If you want more NFL odds and predictions, please follow this link.
How to Watch
- When: Sunday, December 28, 1 pm ET
- Where: Lucas Oil Stadium, Indianapolis, Indiana
- How to Watch: FOX
Jaguars vs. Colts Odds
Game Preview
The Jags beat the Broncos in Denver, and that perfectly shows how good this team is right now. It was 34-20 for Jacksonville, meaning they beat up on the Broncos, who have one of the best defenses in the NFL.
Trevor Lawrence was once again superb, having three passing and one rushing touchdown. His main target here was Parker Washington, who caught 6 passes for 145 yards, one for 63 yards.
As for the Colts, they lost at home to San Francisco on Monday Night Football, 48-27. Their defense didn’t have any solutions for Brock Purdy, who posted 5 touchdowns.
Also, Jonathan Taylor ran 16 times for only 46 yards, and that was the main reason why the Colts lost so badly. Philip Rivers threw for 277 passing yards, including two touchdowns and one pick. Both scoring passes were to Alec Pierce.
Jaguars vs. Colts Head to Head
There were 49 games in the past, with the Colts leading the series, 28-21.
Jaguars vs. Colts Predictions
Jaguars have 6 wins in a row, and the Colts 5 defeats. Therefore, everything is perfectly clear here when it comes to our betting pick.
- Free NFL Picks: Jaguars
NFL
More Predictions
NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread
Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]
NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow
NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]
Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina
Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]
Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly
Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]
Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland
Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]