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Expert prediction

NFL Week 17: Seattle Seahawks vs. Carolina Panthers Preview, Odds, Picks (Dec 28)

  • Nikola Velickovic
  • Dec 23, 2025 at 4:16 PM EST

Pick rationale

Analysis & key factors

  • Seahawks vs. Panthers odds favor Seattle at -395.
  • Seahawks are the 3rd offense and the 2nd defense in the NFL.
  • Panthers have a negative point ratio but top the NFC South.

A lot is at stake here. For the Seahawks, the top of the NFC West and the conference. For the Panthers, the top of the NFC South and the playoff spot.

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How to Watch

  • When: Sunday, December 28, 1 pm ET
  • Where: Bank of America Stadium, Charlotte, North Carolina
  • How to Watch: CBS

Seahawks vs. Panthers Odds

TeamMoneylineSpreadTotals
Seahawks-395-7.542.5
Panthers+310+7.542.5

Game Preview

Seattle is one win ahead of the Rams and the 49ers in the NFC West, and they have to win in Charlotte. Last weekend, we saw them beat the Rams in OT, 38-37, in a wild ending, with the home unit erasing a 16-point deficit.

Sam Darnold was inconsistent, having 270 passing yards, with two touchdowns and picks each, but the rushers had a good day, with 171 yards on the ground, and two touchdowns, one by Kennet Walker III and one by Zach Charbonnet.

Panthers topped the Buccaneers, 23-20, getting the edge in the division and taking over the top spot in the NFC South. Bryce Young looked well, we have to say that, throwing for 2 TDs, 191 yards, and no interceptions.

The difference in this one was one turnover, and luckily for the Panthers, their player won the possession – Lathan Ransom. Meanwhile, Carolin and Young kept their football safe at all times.

Seahawks vs. Panthers Head to Head

Seattle Seahawks lead the series against the Panthers 11-5.

Seahawks vs. Panthers Predictions

It looks like there might be rain on Sunday, so we should bet UNDER immediately. First of all, the defenses will lead the way here, especially with poor weather. The line is 42.5 points, and we have to go with under.

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