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Expert prediction

Colorado vs No. 5 Houston Preview, Odds, Predictions (Feb. 28)

  • Richard Pereira
  • Feb 28, 2026 at 11:24 AM EST

Pick rationale

Analysis & key factors

  • The Buffaloes have struggled on the road with a 1-7 record.
  • The Cougars lost their last three conference matchups.
  • This marks the ninth all-time meeting between the Big 12 programs.

A ranked matchup will take place in the Big 12 as the No. 5 Houston Cougars host the Colorado Buffaloes. The hosts stand tall as strong favorites for the win, displaying the high quality they have to defend homecourt and keep the Buffaloes busy.

MORE: FAU vs Rice Preview, Odds, Predictions (Feb. 11)

How to Watch

  • When: Saturday, Feb. 28, 12 pm ET
  • Where: Fertitta Center, Houston, Texas
  • How to Watch: ESPN2

NCAA Matchup Odds & Lines

TeamOddsSpreadTotals
Colorado-110+19.5O138
Houston-110-19.5U138

Game Preview

The Buffaloes (16-12, 6-9 Big 12) are trying to end the regular season on a positive note, winning their last two games over Oklahoma State and Kansas State. Isaiah Johnson leads Colorado with 16.3 points per game, ranking fourth in the Big 12. Barrington Hargress stands second with 14.6 points, leading the team with 4.4 assists per contest. Sebastian Rancik is third on the team with 12.3 points per game. Bangot Dak averages 10.8 points per game to rank fourth, topping the rebounding and blocking charts with 6.5 rebounds and 1.5 blocks per game.

The No. 5 Cougars (23-5, 11-4 Big 12) continue to boast quality inside the top five of the latest AP Top 25 poll despite going down three spots. However, they have lost their last three games, recently falling to Kansas. Kingston Flemings leads the Cougars with 16.6 points per game, topping the playmaking and steals charts with 5.1 assists and 1.6 steals. On another note, Chris Cenac Jr. leads the Cougars and stands among the Big 12 Top-10 leaders with 7.8 rebounds per game.

Colorado vs Houston Head-to-Head

The two programs have had eight meetings in their history, and the result is 5-3 for the Cougars. The last matchup was in March 2025 when Houston secured a 77-68 win on the road.

Colorado vs Houston Predictions

The Buffaloes will have plenty of difficulty towards pulling off an upset on the road, given their track record. Despite being in poor form, Houston still shines as one of the best teams in the country. They have a lot of motivation to get back on the win column, paving the way for a potential blowout to ensue at Colorado’s expense. Our betting pick here is the Cougars to defend a 19.5-point spread.

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