Southampton vs. Arsenal Preview, Odds, and Pick (Apr 4)

• When: Saturday, April 4, 2026. 3:00 PM ET
• Where: St. Mary’s Stadium, Southampton, England
• How to Watch: ESPN

Match Result	Odds
Southampton	+975
The Draw	+487
Arsenal	-370

Southampton vs. Arsenal Preview

Arsenal’s hopes of an unprecedented quadruple were dashed before the international break after losing to Man City in the EFL Cup final. However, Mikel Arteta’s side will still be targeting three major honors in 2025-26. This weekend’s clash with Southampton is a quarterfinal tie in the FA Cup, with a place at Wembley up for grabs for the winners.

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Southampton Stats & Team News

• Overall Record: 17-12-10
• Home Record: 10-6-3
• Road Record: 7-6-7
• Top Goal Scorer: Adam Armstrong (11)

Championship side Southampton will be the huge outsiders in the betting this weekend, as they bid to reach the final four of the FA Cup for the first time since 2020-21.

The Saints have improved since the appointment of Tonda Eckert, leading them to a realistic chance of finishing in the playoff spots. Southampton have already beaten Premier League opposition in the competition this season after edging past Fulham at Craven Cottage in the fifth round last month.

Injury News:

Wellington (Muscle) Jay Robinson (Muscle) Mads Roerslev (Knee)

Likely Line-Up:

(4-1-4-1): Peretz; Bree, Harwood-Bellis, Stephens, Manning; Downes; Fellows, Azaz, Charles, Archer; Larin

Arsenal Stats & Team News

• Overall Record: 21-7-3
• Home Record: 12-2-1
• Road Record: 9-5-2
• Top Goal Scorer: Viktor Gyokeres (16)

The first major setback in Arsenal’s 2025-26 season was delivered before the international break, as the Gunners underperformed and were subsequently easily beaten by Man City in the EFL Cup final.

However, Arteta’s side could yet end the season with three major honors. A number of Arsenal players withdrew from international duty over the weekend, but it remains to be seen whether any of the issues were serious setbacks. Arsenal have eased through the FA Cup against lower league opposition to this point, beating Portsmouth, Wigan, and Mansfield in the previous three rounds.

Injury News:

Martin Zubimendi (Knee) Declan Rice (Other) Bukayo Saka (Other) Noni Madueke (Other) Leandro Trossard (Hip) Gabriel (Knee) Eberechi Eze (Calf) William Saliba (Ankle) Martin Odegaard (Knee) Jurrien Timber (Ankle) Mikel Merino (Foot)

Likely Line-Up:

(4-2-3-1): Arrizabalaga; White, Salmon, Mosquera, Calafiori; Norgaard, Dixon; Dowman, Havertz, Martinelli; Jesus

Head-to-Head Trends

• Arsenal have won 25 of the last 48 meetings between the sides, with Southampton winning just nine times over the same period.
• Southampton have avoided defeat in two of the last three clashes with Arsenal at St. Mary’s.

Southampton vs. Arsenal Pick

The pressure will be back on Arsenal following their no-show in the EFL Cup final before the international break. However, against lower-league opposition, they should face few issues in securing their spot in the semi-finals.

Free Pick:

• Arsenal (-370)