Serie A Round 3 Predictions: Best Bets, Match Preview & Top Odds

The 2026–27 Italian Serie A season heads into Gameweek 3 (September 4–7, 2026) featuring several classics. There will be fire all across Italy over the next few days.

Defending champions Inter Milan host Napoli at the San Siro. These two sides have been direct title rivals in the past several years. These two sides won the previous 4 trophies, splitting two titles each.

Later that day, AS Roma take on Atalanta at the Stadio Olimpico. These teams will battle for the UCL spot, so points here are worth a lot.

Finally, the weekend caps off with a massive showdown between Juventus and AC Milan at the Allianz Stadium in Turin. We don’t really need to say anything here. These clubs are an absolute magnet for fans, even though they aren’t posting results like they used to.

Below is the complete fixture preview, best betting odds, and key match breakdowns for Gameweek 3.

Serie A Gameweek 3 Best Bets & Top Value Angles

• Best Moneyline: FC Inter Milano (-145) vs. SSC Napoli
• Best Both Teams to Score (BTTS): A.S. Roma vs. Atalanta BC
• Top Value Over/Under: ACF Fiorentina vs. Torino FC (Under 2.5 Goals)

Gameweek 3 Best Bets

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FC Inter Milano vs. SSC Napoli Prediction & Odds

Kickoff: Saturday, September 5 | San Siro, Milan

Match Preview

The reigning champions, Inter Milan, return to the Meazza after a 0-1 road win over Cagliari. Before that, Nerazzurri smashed Monza at home, 4-1. Napoli arrives seeking to bounce back from a surprising 2–1 loss at Como in Matchday 2. That’s something the 2025 champs didn’t expect. The last three meetings in Milan have ended in a tie, but overall, Napoli hasn’t beaten Inter in Milan in a Serie A fixture since 2017.

• Best Bet: Inter Milan

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Genoa vs. Como Prediction & Odds

Kickoff: Friday, September 4 | Luigi Ferraris, Genoa

Match Preview

After Como defeated Napoli on the road, 1-2, we have to bet on their victory in this event. Yes, we are aware that they play in the Champions League next week, but the season is still early, so there’s no fatigue or injury accumulation. Genoa is a mediocre team that didn’t score a goal in the opening 180 minutes of Serie A football and, furthermore, played poorly during the preseason.

• Best Bet: Como

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A.S. Roma vs. Atalanta BC Prediction & Odds

Kickoff: Saturday, September 5 | Stadio Olimpico, Rome

Match Preview

Roma enter Gameweek 3 in blistering offensive form after victories over Fiorentina and Lecce, both 4-0. Fantastic Malen is on fire these days and carries the team on his back. Atalanta claimed maximum points from their first two outings, presenting tough defense and a very efficient and rational offense. However, La Dea has strong offensive potential and can score against any team in Serie A.

• Best Bet: Both Teams to Score (BTTS)

Prop Pick of the Round

Malen to score and Roma to win

The Dutch fella is going crazy since he came to Roma. After an explosive second part of the previous year, he opened the current campaign with five goals in two games. A hat-trick against Fiorentina and a brace on the road in Lecce propelled him to the top of the Serie A goalscoring list. His scoring and Roma winning would be a perfect prop pick for bettors.