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NFL Odds, Predictions: Commanders vs. Cowboys Week 2 Preview & Picks (Sep 20)

  • Nikola Velickovic
  • Sep 16, 2026 at 7:31 AM EDT

Pick rationale

Analysis & key factors

  • Commanders vs. Cowboys odds favor Dallas at -220.
  • Dallas lost to the Giants on the road in Week 1, 28-20.
  • The Commanders also lost to the Eagles, 24-22, at home.

This is one of the classic NFL rivalries. Both teams lost their opening games, which only emphasizes the need for a win here. That’s why we expect fireworks in Arlington.

Check for more NFL odds and picks here.

How to Watch

  • When: Sunday, September 20, 2026, 4:25 PM ET
  • Where: AT&T Stadium, Arlington, Texas
  • How to Watch: FOX

Commanders vs. Cowboys Odds

TeamMoneylineSpreadTotals
Commanders+180+4.550.5
Cowboys-220-4.550.5

Game Preview

The Commanders suffered a heartbreaking 24-22 road loss to the Philadelphia Eagles in Week 1. Dan Quinn’s team showed strong fight late in the game, coming up just short on a potential game-tying two-point conversion drive in the final minute.

Jayden Daniels threw for 164 yards and 2 touchdowns, and he also ran for 31. He found veteran WR Stefon Diggs for one score, while the other went to Antonio Williams. Overall, the offense looked solid against a tough, formidable Eagles defense.

NFL Week 2 Predictions: Best Bets, Odds & Upset Picks

The Cowboys fell in New York vs. the Giants, 28-20. Brian Schottenheimer’s crew was constantly behind the hosts, unable to make that one push and level with the NYG. There were two reasons for that: No. 1, poor run game, No. 2, lack of pass-rush pressure.

Dallas didn’t have a single sack in this event. Also, the offense generated just 69 rushing yards. Javonte Williams ran for 41 on 12 carries, while Prescott added 14 yards on the ground. Meanwhile, Prescott threw for just 175 yards, two TDs and one pick.

Commanders vs. Cowboys Predictions

Prescott and the boys are a completely different kind of animal at home, where they unleash their full offensive potential. As for the Commanders, their offense looked sharp in the opener, and that’s why we have to bet on Over 50.5 points.

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