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NFL Odds, Predictions: Chargers vs. Bills Week 3 Preview & Picks (Sep 27)

  • Nikola Velickovic
  • Sep 22, 2026 at 4:00 AM EDT

Pick rationale

Analysis & key factors

  • Chargers vs. Bills odds favor Buffalo at -270.
  • LA Chargers are 0-2.
  • The Bills scored 77 points in the first two games.

Josh Allen wants another NFL MVP award and a Super Bowl title. The way the Bills play now, that’s realistic. Meanwhile, the Chargers are in trouble, as they have one hell of a schedule ahead.

Check for more NFL odds and picks here.

How to Watch

  • When: Sunday, September 27, 1 PM ET
  • Where: Highmark Stadium, Orchard Park, New York
  • How to Watch: CBS

Chargers vs. Bills Odds

TeamMoneylineSpreadTotals
Chargers+250+750.5
Bills-310-750.5

Game Preview

The Los Angeles Chargers (0-2) lost their first two games by the same score, 26-14. To make it worse, both were at home: one against the Cardinals and the other against the Raiders. Now, Jim Harbaugh’s unit hits the road to face one of the best teams in the NFL.

LAC had three turnovers, two picks by Herbert, and one fumble by Omarion Hampton. As usual, Herbert’s protection was below average, and we are pretty sure this is the main reason why LAC’s offense isn’t productive. He was hit 9 times against the Raiders, meaning he takes a lot of beating.

The Buffalo Bills (2-0) host their second straight home game. They would smash the Detroit Lions on Week 2 Thursday Night Football, 41-31. Josh Allen and his crew were fantastic, delivering 77 points in the opening two rounds. Allen has 5 touchdown passes right now and 582 passing yards. TE Dalton Kincaid caught 225 of those, and the connection between the two is superb for the moment.

A defensive breakthrough is LB Greg Rousseau, who already bagged 4 sacks. But not only that, the 26-year-old has forced 3 fumbles so far and is the pylon of the Bills’ defense. He was productive in the previous years, yet never like this.

Chargers vs. Bills Predictions

Justin Herbert is an easy target, and we are pretty sure Rousseau and the boys will create plenty of trouble for the Chargers’ QB. On the other hand, Allen is in his usual Superman mode, so the Bills should have an easy win here.

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