Expert prediction
NFL Odds, Predictions: Cardinals vs. 49ers Week 3 Preview & Picks (Sep 27)
Pick rationale
Analysis & key factors
- Cardinals vs. 49ers odds favor San Francisco by 8.5 points.
- Niners’ Brock Purdy threw 5 touchdowns and one interception.
- Cardinals lost to the Seahawks last week, 31-7.
This NFC West divisional matchup always brings interesting developments. The 49ers are the favorites, as they want to keep up the pace and maintain their perfect streak.
Check for more NFL odds and picks here.
How to Watch
- When: Sunday, September 27, 4:05 PM ET
- Where: Levi’s Stadium, Santa Clara, California
- How to Watch: FOX
Cardinals vs. 49ers Odds Week 3
Game Preview
Cardinals (1-1) lost last weekend at home to the Super Bowl champions, Seahawks, 31-7. It was obvious right away that Arizona had nothing to hope for in this one. Jacoby Brissett was limited to just 95 yards, a touchdown, and an interception.
Seattle’s defense was ruthless, and the Cardinals managed only 151 yards from scrimmage. They also went 3-for-12 on 3rd-down conversions, and that pretty much summarizes their offensive display.
49ers (2-0) blasted the sorry Miami Dolphins, 35-13, maintaining the good morale. After taking down the Rams in Australia, they’ve kept at the same pace, routinely handling the guests from Florida.
The O-line protected Purdy perfectly, allowing no sacks. Against the Fins, Purdy threw for 287 yards and 2 TDs, and he also ran for 30 yards for another score. Both of his touchdown passes went to Christian McCaffrey.
Cardinals vs. 49ers Predictions
San Francisco is the better team, especially on the defensive side of the ball. We saw how the Cards worked under pressure against the Seahawks at home. Now they face a similar rival on the road, meaning they’ll lose without any problems.
- Free NFL pick: San Francisco 49ers -8.5
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