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NFL Odds, Predictions: Patriots vs. Jaguars Week 3 Preview & Picks (Sep 27)

  • Nikola Velickovic
  • Sep 24, 2026 at 4:41 AM EDT

Pick rationale

Analysis & key factors

  • Patriots vs. Jaguars odds favor Jacksonville at -155.
  • Jags’ Bhayshul Tuten averages 4.7 rushing yards per carry.
  • Drake Maye has 1 TD and 4 interceptions in the opening two games.

AFC playoff picture will have huge implications depending on the outcome of this one. Pats and the Jags are direct playoff rivals, and the result here is very important.

Check for more NFL odds and picks here.

NFL Week 3 Preview

  • When: Sunday, September 27, 2026, 1:00 PM ET
  • Where: EverBank Stadium, Jacksonville, Florida
  • How to Watch: CBS

Patriots vs. Jaguars Odds

TeamMoneylineSpreadTotals
Patriots+135+3.545.5
Jaguars-155-3.545.5

Game Preview

Following a loss in Seattle, the Patriots (1-1) have bounced back with a commanding win at home over the Steelers, 20-3. Everything worked almost perfectly for the Pats, who squished Pittsburgh in every aspect of play.

First of all, they sacked Aaron Rodgers 4 times, limiting him to just 187 passing yards, no touchdowns, and picking the 4-time MVP once. We can’t say that Drake Maye had his night (208 yards, 0 TDs and one pick), but the defense was excellent.

Jags (1-1) lost to the Broncos 20-13 at Mile High last weekend. Denver’s pass rush harassed Trevor Lawrence, who threw for just 189 passing yards, no TDs, and one interception.

Meanwhile, Jacksonville’s run game was also poor, with only 95 yards on the ground. RB Bhayshul Tuten had 65 rushing yards on 13 carries for one TD. Overall, a mediocre performance for the Florida franchise.

Patriots vs. Jaguars Predictions

Now, the Jags are a completely different team when playing at home. They were 7-2 at home in 2025. Jacksonville faces a sluggish Drake Maye, whose performances are masked behind a solid defense, so we would pick the Jaguars to win this one and cover the spread.

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