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NFL Odds, Predictions: Broncos vs. Chargers Week 5 Preview & Picks (Oct 11)

  • Nikola Velickovic
  • Oct 5, 2026 at 6:38 PM EDT

Pick rationale

Analysis & key factors

  • Broncos vs. Chargers odds favor Denver at -185.
  • Chargers have allowed 12 sacks so far, 4th most in the NFL this year.
  • Broncos have a poor run offense and defense.

The Chargers are in hell, and it doesn’t look good for them with the Denver Broncos coming to town. This AFC West rivalry comes at an important moment, because both teams simply have to win.

Here is the full NFL Week 5 odds and picks list.

How to Watch

  • When: Sunday, October 11, 4:05 PM ET
  • Where: SoFi Stadium, Inglewood, California
  • How to Watch: CBS

Broncos vs. Chargers Odds

TeamMoneylineSpreadTotals
Broncos-185+3.542.5
Chargers+155+3.542.5

Game Preview

Denver Broncos lost to the 49ers at Levi’s, 24-14. It was a grueling game in which one lost fumble by Marvin Mims Jr. practically cost them a win. We can’t say the 49ers were that much better, but they still came out on top in the end.

Once a very formidable defense, it is now 28th in the NFL in allowed yards, 375. Also, Denver’s run defense is very bad: 30th with 142.8 ypg, while the offense produces 81.2, 4th worst.

With 0-4, the Chargers’ season could be declared a waste pretty soon. Though, we need to say that in none of the previous two road games, in Buffalo and Seattle, did they get outplayed.

But disastrous QB protection hurts this team most. Justin Herbert has already been sacked 12 times. He is at increased risk of injury, and Chargers management looks ridiculous for staying inactive while their top star gets beaten up.

Broncos vs. Chargers Predictions

Sure, the Chargers play at home, but the Broncos are a better team now. If they play as they did against the 49ers last week, then LAC has no chance of beating them. For the moment, they can’t protect Herbert, and the Broncos have a solid pass rush.

How to bet on the Broncos vs. Chargers (Week 5)

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