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NFL Odds, Predictions: Saints vs. Giants Week 6 Preview & Picks (Oct 18)

  • Nikola Velickovic
  • Oct 13, 2026 at 12:24 AM EDT

Pick rationale

Analysis & key factors

  • Saints vs. Giants total is 44.5 points.
  • New Orleans Saints allow the 2nd-most points in the league, 30.2.
  • The Giants haven’t lost in their last three games: 2 wins and 1 tie.

The Giants are back home, where they haven’t lost this year. On the other hand, the Saints opened the season well, yet slowed down afterward, recording three consecutive defeats.

Here is the full NFL Week 6 odds.

How to Watch

  • When: Sunday, October 18, 1:00 PM ET
  • Where: MetLife Stadium, East Rutherford, New Jersey
  • How to Watch: FOX

Saints vs. Giants Odds

TeamMoneylineSpreadTotals
Saints-110+1.545.5
Giants-110-1.545.5

Game Preview

Saints were held to only 142 yards from scrimmage against the Vikings, losing that game at home, 23-13. QB Tyler Shough, one of the league’s best passers until this game, threw for just 96 yards with two picks looking terrible.

We really have nothing good to say about the Saints defense, which happens to be one of the worst in the NFL. Right now, New Orleans allows 30.2 points per game, the second-most in the league. Brandon Staley will have to do better if he wants to keep his job as a defensive coordinator.

The Giants didn’t win, yet they didn’t lose either in Washington. The game against the Commanders ended in a 27-27 tie, keeping the NYG unbeaten in their 3rd straight appearance.

QB Jameis Winston threw for three TD passes and 326 yards without a pick. Malik Nabers caught one of them, and Isaiah Likely caught two. The Giants defense recorded 5 sacks in this game, up from three in the first 4 weeks combined.

Saints vs. Giants Predictions

Why bet on Over 45.5 points here? The Giants’ defense has flaws, while Winston is getting his groove back on offense. As for the Saints, their defense is terrible, but the offense is much better. Combine these two and the outcome is Over.

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