Expert prediction
MLS Predictions: Best Bets, Odds & Picks For This Weekend (Oct 17-18)
Pick rationale
Analysis & key factors
The action in the MLS steps up a gear this weekend, as just under a month remains of the regular season. Inter Miami will be on the road as they pursue Nashville SC at the top of the Eastern Conference, while there will be fascinating showdowns between Orlando City and D.C. United, and Houston Dynamo and FC Dallas in the playoff chase. You can find our best bets and MLS predictions for this weekend here.
MLS Best Bets For This Weekend & Top Value Picks
- Best Pick: Inter Miami (vs. Atalanta United)
- Best Both Teams to Score (BTTS): Atalanta United vs. Inter Miami
- Best Value Over/Under: Minnesota United vs. St. Louis SC (Over 2.5 Goals)
ALSO SEE: Breeders’ Cup Classic Picks, Odds, Leading Contenders, Betting Insights & Analysis
Key Fixture Breakdown & Predictions
Atalanta United vs. Inter Miami Prediction & Odds
Kickoff: Saturday, October 17 | 7:30 PM ET | Mercedes-Benz Stadium, GA
Match Preview
Inter Miami bounced back to their best form in the MLS last weekend, beating D.C. United 4-0 to snap a five-game winless run. Miami appear to be chasing Nashville in vein, but they will still be hoping to build momentum across the remaining six rounds to go into the playoffs with the best possible momentum.
They’ll be heavily expected to overcome a struggling Atalanta United this weekend, as the hosts have failed to win in four home matches at Mercedes Benz Stadium. However, BTTS also provides value, as despite their issues, Atalanta have scored at least once in their previous three.
- Best Bet: Inter Miami & BTTS
LA Galaxy vs. San Diego FC Prediction & Odds
Kickoff: Saturday, October 17 | 10:30 PM ET | Dignity Health Sports Park, CA
Match Preview
The LA Galaxy have re-emerged as a leading playoff contender in the Western Conference, and a victory on Saturday evening could take them to within striking distance of the top seven spots.
San Diego’s recent form offers little confidence, as they have failed to win in six, which includes a run of four without a win on the road. Despite a recent loss, it is worth siding with the Galaxy to maintain their excellent home record, as they have avoided defeat in their last five at Health Dignity Health Sports Park.
- Best Bet: LA Galaxy
FC Cincinnati vs. Columbus Crew Prediction & Odds
Kickoff: Sunday, October 18 | 5:00 PM ET | TQL Stadium, Ohio
Match Preview
A significant showdown in the context of the chase for a playoff spot in the Eastern Conference is set for TQL Stadium, as FC Cincinnati host the Columbus Crew. Cincinnati sit ninth, but they are just three points clear of NYCFC in the final playoff spot.
Cincinnati’s form since the start of August has been rocky, winning just once in the last seven rounds. Columbus have shown battling qualities in recent rounds, winning two of their previous three. The Crew have also won two of the previous three head-to-heads in the MLS.
- Best Bet: Columbus Crew
MLS Best Parlay Pick This Weekend
Combining multiple picks will create the best value when making MLS predictions this weekend. Therefore, a parlay bet could return healthy amounts. Home wins for Orlando, Seattle Sounders, and the Philadelphia Union are musts. Meanwhile, wins for the LA Galaxy and Inter Miami will boost the odds.
- Best MLS Parlay Bet: Inter Miami, Seattle Sounders, Orlando, Philadelphia Union & LA Galaxy All To Win
Best MLS Predictions For All Matches This Weekend
| Date | Time | Match | Pick |
|---|---|---|---|
| Saturday, Oct 17 | 2:30 PM ET | Philadelphia Union vs. Charlotte FC | Philadelphia Union |
| Saturday, Oct 17 | 4:30 PM ET | Minnesota United vs. St. Louis | BTTS |
| Saturday, Oct 17 | 7:30 PM ET | Atalanta United vs. Inter Miami | Inter Miami |
| Saturday, Oct 17 | 7:30 PM ET | New England Revolution vs. Chicago Fire | New England Revolution |
| Saturday, Oct 17 | 7:30 PM ET | NYCFC vs. LAFC | Over 2.5 Goals |
| Saturday, Oct 17 | 7:30 PM ET | NY Red Bulls vs. Toronto FC | NY Red Bulls |
| Saturday, Oct 17 | 7:30 PM ET | Orlando City vs. D.C. United | Orlando City |
| Saturday, Oct 17 | 8:30 PM ET | Austin FC vs. Vancouver Whitecaps | Vancouver Whitecaps |
| Saturday, Oct 17 | 8:30 PM ET | Houston Dynamo vs. FC Dallas | Houston Dynamo |
| Saturday, Oct 17 | 8:30 PM ET | Sporting KC vs. Real Salt Lake | Over 2.5 Goals |
| Saturday, Oct 17 | 10:30 PM ET | LA Galaxy vs. San Diego | LA Galaxy |
| Saturday, Oct 17 | 10:30 PM ET | Portland Timbers vs. Colorado Rapids | Portland Timbers |
| Saturday, Oct 17 | 10:30 PM ET | San Jose Earthquakes vs. Nashville | Nashville |
| Saturday, Oct 17 | 10:30 PM ET | Seattle Sounders vs. CF Montreal | Seattle Sounders (-1.5) |
| Sunday, Oct 18 | 5:00 PM ET | Cincinnati vs. Columbus Crew | Under 3.5 Goals |
How to Bet On MLS This Weekend
These are the best sportsbooks for U.S. bettors to place wagers on the MLS today:
Sportsbook ratings
BetOnline
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BetUS
RegionsCanadaUnited States
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Lucky Rebel
RegionsCanadaUnited States
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Minimum deposit$50
Soccer
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