Skip to content

Expert prediction

MLB: Giants vs Padres Odds, and Picks (Apr 29)

  • Keith McCarthy
  • Apr 28, 2023 at 5:02 PM EDT

Pick rationale

Analysis & key factors

  • The Giants were shut out, 6-0, against the Cardinals.
  • San Diego fell to the Cubs, losing by a score of 5-2.
  • San Francisco is 483-436 in their all-time history against the Padres.

San Francisco (11-14) and San Diego (13-14) meet for an intriguing NL West rivalry series. Both teams are close to 1st place in a bad division, and will be aiming to climb the standings during this Mexico City series.

Jump to:


How to Watch

  • Where: Estadio Alfredo Harp Helú, Mexico City, MX
  • When: Saturday, April 29, 2023, at 6:05 p.m ET
  • How to Watch: NBC Sports

Odds

TeamMoneyline
Giants
Padres

Game Preview

San Francisco had their 5-game winning streak snapped on Thursday, falling to 11-14 on the season. They still remain just 2.5 games out of 1st place in the NL West, thanks to no single team doing exceptionally well in that division. The Giants regressed last season after winning over 100 games in 2021, and started this season very slow as well. They’ll be aiming to build on their recent winning ways in this rivalry series.

The Padres fell to below .500 with their loss to the Cubs. They sit 1.5 games out of 1st in the NL West, but have gone 6-9 over their last 15 games. In their last 7 losses, they were outscored 42-5. However, they’ve also played one of the MLB’s toughest schedules, with 22 out of 27 games coming against a team ranked 1st or 2nd in their division. The Padres will get a break against the 4th-place Giants, needing to capitalize.


Prediction

This is a game that could very well go either way. San Diego is currently just 1 game ahead of San Francisco, and neither team has home-field advantage in an international game in Mexico City. Both starting pitchers have struggled this season, but Joe Musgrave (5.40 ERA) of the Padres has been marginally better than Sean Manaea (6.61 ERA) of the Giants. I trust San Diego’s offense more too.

MLB Picks:

MLB

More Predictions

MLB Insight

World Series: Rays vs. Brewers Game 4 Picks, Odds & Betting Analysis

There is a sense of inevitability in the 2026 World Series, as Milwaukee Brewers require just one more victory to win the biggest MLB  honor for the first time. History will be against the Tampa Bay Rays, as no team has ever recovered from 3-0 down to win the World Series. You can find the […]

Alex Dudley 3 min read

MLB Insight

World Series: Rays vs. Brewers Game 3 Picks, Odds & Betting Analysis

The intense action in the World Series steps up a gear on Monday, as the first game of the series to see the Tampa Bay Rays have home-field advantage will be staged. It will be a must-win encounter for the hosts, following defeats in Games 1 and 2 at American Family Field. A victory for […]

Alex Dudley 3 min read

MLB Insight

World Series: Brewers vs. Rays Game 2 Picks, Odds & Betting Analysis

The intensity increases in the World Series on Saturday evening, as Game 2 between the Milwaukee Brewers and Tampa Bay Rays is set for American Family Field. Milwaukee will be hoping for a fast start in their opening two games, but the Rays have been consistent on their travels in the postseason. The latest odds […]

Alex Dudley 3 min read

MLB Insight

World Series: Brewers vs. Rays Game 1 Picks, Odds & Betting Analysis

The high-pressure action in the MLB reaches new heights on Oct. 23, as the 2026 World Series gets underway. Both the Tampa Bay Rays and Milwaukee Brewers will be targeting first honors, and whichever team deals with the pressure the best will likely seize the advantage. The Brewers will have the Game 1 home-field advantage, and you […]

Alex Dudley 3 min read

MLB Insight

World Series 2026: Brewers vs. Rays Picks, Series Odds & Betting Analysis

History awaits in the MLB postseason, as a first-time World Series champion will be crowned in 2026. The Tampa Bay Rays are hoping that it’s their third time lucky, having lost in the 2008 and 2020 World Series, while the Milwaukee Brewers chase a first honor in their return to the World Series for the […]

Alex Dudley 3 min read