Expert prediction
NFL Week 1: Bills vs. Texans Preview, Odds, Predictions (Sep 13)
Pick rationale
Analysis & key factors
- Bills vs. Texans odds favor Buffalo at -110.
- Texans had the second-best scoring defense last year, 17.4 ppg.
- Josh Allen won the NFL MVP last year, while James Cook led the league in rushing yards.
The MVP comes to Texas, as Josh Allen and the Bills come to test Houston’s defense.
Check more NFL odds here.
How to Watch
- When: Sunday, September 13, 2026, 1:00 PM ET (7:00 PM CEST)
- Where: NRG Stadium, Houston, Texas
- How to Watch: CBS
Bills vs. Texans Week 1 Odds
Game Preview
Josh Allen will be under pressure right away. James Cook will be as well. These two offensive superstars are about to face one of the toughest defenses in the NFL, if not the toughest.
Bills’ defense will be different from before. New defensive coordinator Jim Leonhard decided to switch back to a 3-4 base. That could bring plenty of positives. At least they aren’t scouted as they were in the past.
Houston didn’t have any need to change anything in its defense. Last year it was the second-best in allowing points, with only 17.2 per game. Will Anderson is among the top 10 players in the NFL, and there are plenty of his teammates on defense who are elite at their respective positions.
The Texans’ biggest problem is their QB. We saw Stroud posting 2 touchdown passes and 5 picks in two games. His passer rating was 51.8, and that says it all. His performance against the Patriots brought plenty of doubts.
Bills vs. Texans Head to Head
Houston leads the all-time series, 8-5. The last meeting was in November 2025, when Texans beat Buffalo in Houston, 23-19.
Buffalo Bills vs. Houston Texans Predictions
Stroud will need time to regain his confidence, because last year’s ending was pretty stressful for him. This, and the fact that the Bills changed their defense, is the only reason why we take Buffalo to win here. Also, the Bills can endure high-scoring games, while the Texans can’t.
- Free NFL Pick: Buffalo Bills
NFL
More Predictions
NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread
Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]
NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow
NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]
Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina
Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]
Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly
Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]
Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland
Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]