Expert prediction
NFL Odds, Predictions: Lions vs Cardinals Week 5 Preview & Picks (Oct 11)
Pick rationale
Analysis & key factors
- The Lions came up short against the Panthers, losing 32-26 on the road.
- Arizona was unable to hold off the battered Giants, falling to them 36-24.
- These teams last met on September 22, 2024, in a game that the Lions won 20-13.
- Detroit Lions -4.5
In this week’s Lions vs Cardinals matchup, two NFC teams battle to get a leg up in the standings. Detroit is slightly favored to win, despite being on the road, as they seek to earn their first win of the year away from home. Arizona will put them to the test in this one.
Lions Seek Bounce Back Road Win
The Lions dropped to 2-2 last week after losing to the Panthers. They remain in contention in the early going, but now find themselves two games behind the 4-0 Vikings in the NFC North. Detroit is 2-0 at home, but 0-2 on the road, facing another road test in this game against the Cardinals. This should be a winnable game to get into the win column away from home, but they’ll need to avoid another late-game collapse.
Cardinals in Need of a Victory
The Cardinals fell to 1-3 last week after failing to fend off Jameis Winston and the Giants. Arizona has now lost three games in a row since winning the opener against the now 0-4 Chargers. It’s been a string of losings seasons that just keeps growing longer and longer and the Cardinals find themselves in a tough spot. Despite QB Jacoby Brissett exceeding expectations, Arizona’s defense has heavily held them back.
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Lions vs Cardinals NFL Pick
Detroit may be on the road for this game, but they hold a notable advantage in skill over the Cardinals. They won’t finish the year winless on the road, so expect that streak to end sooner rather than later. Arizona’s loss to the Giants illustrated some major holes that the Lions are very likely to exploit. They should win this one by more than enough to cover the spread.
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