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Expert prediction

NFL Most Rushing Yards Outright Odds 2025

  • Nikola Velickovic
  • Jul 22, 2025 at 11:19 AM EDT

Pick rationale

Analysis & key factors

  • NFL most rushing yards odds highlight two names – Saquon Barkley and Derrick Henry.
  • Henry led the league twice in rushing yards, while Barkley did that last year.
  • Falcons’ Bijan Robinson is +1000, while Jahmyr Gibbs sits at +1400.

According to these NFL odds, Saquon Barkley and Derrick Henry are far ahead in the conversation for the rushing yards leader. All the other players have way slimmer prospects than the two mentioned.

On this link you can find more information about the NFL awards, odds for the same and top contenders.

NFL Most Rushing Yards Odds

PlayerOdds
Saquon Barkley+270
Derrick Henry+400
Christian McCaffrey+1000
Jonathan Taylor+1000
Bijan Robinson+1000

NFL Most Rushing Yards Contenders

Saquon Barkley had an unreal season. He played almost three quarters of Philly’s snaps, recording 2,005 rushing yards and winning the Super Bowl. That’s why he’s +270 to win this award.

Derrick Henry is behind at +470, with the Ravens’ RB and one of the most dominant rushers in the last two decades being the focal point of Baltimore’s attack. Yes, we’ve said that despite knowing that Lamar plays alongside King Henry. Do remember that he rushed for 1,921 yards and 16 touchdowns last year.

CMC Coming Back, Bucky Irving’s Explosion?

Christian McCaffrey is one of the top favorites for winning the NFL Comeback Player of the Year award. He, Colts’ Jonathan Taylor, and Falcons’ Bijan Robinson are all +1000 to have the most rushing yards at the end of the season.

Both McCaffrey and Taylor already led the league in rushing yards in 2023 and 2021, respectively.

Tampa Bay’s Bucky Irving amazed everyone with his rookie year. He appeared 17 times on the field, though as a starter only 3 times. In the end, the 22-year-old from Chicago had 1,122 rushing yards. So, yes, this guy has potential. He’s young, strong, still healthy, and one season more experienced.

Honorable Mentions

Josh Jacobs is a great RB, and he led the league in rushing yards in the past. However, despite being the top ground weapon in Green Bay, the Packers are more pass-oriented. Najee Harris, who is now in the Chargers, could be a surprise, due to Harbaugh’s run-play style.

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