Expert prediction
NFL Odds, Predictions: Cardinals vs. Rams Week 6 Preview & Picks (Oct 18)
Pick rationale
Analysis & key factors
- Cardinals vs. Rams odds favor the LA team by 13.5 points.
- LAR lost to the Bills after OT last week, 37-34.
- Cardinals allow the most points in the NFL, 32.4 points.
This is an NFC West matchup, where the lines heavily favor the Rams. The Cardinals have four straight losses, while the Rams sit at 2-3 after a tough schedule.
Here is the full NFL Week 6 odds.
How to Watch
- When: Sunday, October 18, 4:05 PM ET
- Where: SoFi Stadium, Inglewood, California
- How to Watch: FOX
Cardinals vs. Rams Odds
Game Preview
Cards lost to the Lions at home, 45-21. Their defense is terrible in all aspects of play. It ranks bottom 10 in allowed scrimmage, passing, and rushing yards, and is officially the worst scoring defense, allowing 32.4 points per game. The offense is somewhat better, yet still pretty limited and fragile.
Arizona lost the previous 4 matches. In each of those games, the team allowed 31 or more points, and in the last 3, it gave up 117 points combined.
The Rams played one hell of a game against the Bills on Monday Night Football, but they lost 37-34 in overtime. They had a chance to win, but Harrison Mevis’ field goal attempt was blocked in overtime.
Sean McVay’s unit limits rivals to just 285.2 yards from scrimmage per game, the 3rd-fewest in the league. However, the Rams allow 20 points and have problems restraining the rival’s run game. This often leads to big plays that hurt them, and we saw that on Monday night.
Cardinals vs. Rams Predictions
Stafford and the boys couldn’t ask for a better opponent right now. They’re facing a demoralized, weak rival with the NFL’s worst defense. So it’s the Rams covering the spread here.
- Free NFL pick: Rams -13.5
NFL
More Predictions
NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread
Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]
NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow
NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]
Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina
Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]
Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly
Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]
Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland
Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]