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Expert prediction

NFL Odds, Predictions: Colts vs. Steelers Week 5 Preview & Picks (Oct 11)

  • Nikola Velickovic
  • Oct 5, 2026 at 11:40 AM EDT

Pick rationale

Analysis & key factors

  • Colts vs. Steelers odds set hosts as minimal favorites at -130.
  • Colts allow the second-most yards per game, 392.2.
  • TJ Watt has 4.5 sacks so far.

At the end of the season, this game could have massive implications for the AFC playoffs. Both teams are 2-2 right now and need to win this one not only to get back to positive territory, but to gain a potential tiebreaker.

Here is the full NFL Week 5 odds and picks list.

How to Watch

  • When: Sunday, October 11, 1:00 PM ET
  • Where: Acrisure Stadium, Pittsburgh, Pennsylvania
  • How to Watch: CBS

Colts vs. Steelers Odds

TeamMoneylineSpreadTotals
Colts+110+2.544.5
Steelers-130-2.544.5

Game Preview

The Indianapolis Colts travel to Pittsburgh confident after a 30-13 victory over Washington at Tottenham Stadium. QB Daniel Jones didn’t do well in this one, but Jonathan Taylor had 2 TDs. He has 6 TDs this year, 3rd most in the NFL.

Defense allows the second-most yards per scrimmage (392.2), and that’s the biggest issue for the unit. Yes, the Colts have a potent attack, but their defense tends to ruin everything Jones, Taylor, and the boys generate up front.

Steelers lost to the Browns on Thursday Night Football. They allowed a game-winning drive and a 56-yard FG to lose. Aaron Rodgers’ protection was terrible, as he suffered 5 sacks. Also, he had 3 TDs and two picks.

On the other hand, the Steelers’ defense had only 5 QB hits and 2 sacks, which is the main reason why Pittsburgh failed to triumph. What goes under the radar is that Rodgers threw 40 times and completed only 22. His receivers dropped the ball too often.

Colts vs. Steelers Predictions

This game takes place in Pittsburgh, outside, where the Steelers rarely lose. That is the sole reason why we bet on their win here. That and the fact that the Colts’ defense is terrible.

How to bet on the Colts vs. Steelers (Week 5)

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