Skip to content

Expert prediction

NFL Odds, Predictions: Raiders vs. Chargers Week 2 Preview & Picks (Sep 20)

  • Nikola Velickovic
  • Sep 16, 2026 at 7:28 AM EDT

Pick rationale

Analysis & key factors

  • Raiders vs. Chargers odds favor the LA team at -300.
  • Ashton Jeanty debuted with 147 scrimmage yards and two touchdowns.
  • The Chargers lost to the Cardinals 26-14 in Week 1.

The Raiders won the season opener, but now face a much tougher challenge. LVR heads to Los Angeles to meet AFC West rivals the Chargers.

Check for more NFL odds and picks here.

How to Watch

  • When: Sunday, September 20, 2026, 4:05 PM ET
  • Where: SoFi Stadium, Inglewood, California
  • How to Watch: CBS

Raiders vs. Chargers Odds

TeamMoneylineSpreadTotals
Raiders+240+6.543.5
Chargers-300-6.543.5

Game Preview

The Las Vegas Raiders started the season with a 27-13 victory over the Miami Dolphins in Week 1. Klint Kubiak’s offensive scheme suited well for rookie RB Ashton Jeanty, who shined in this event. He had 102 rushing yards, 45 receiving yards, and two touchdowns, making a very good NFL debut.

Kwity Paye was superb on the defensive side, racking up two sacks and 6 tackles. The hard defensive end also posted 4 QB hits, and the Raiders overall had 11, unleashing quite a beating on the Fins’ starting passer Malik Willis.

NFL Week 2 Predictions: Best Bets, Odds & Upset Picks

The Chargers fell to the Arizona Cardinals, 26-14, in Glendale, suffering an unexpected loss. Jim Harbaugh’s defense fell apart, allowing 393 total yards, while, on the other hand, the Chargers’ run game struggled badly, producing only 81 yards.

Quarterback Justin Herbert threw for 209 yards and one touchdown, with one pick and three sacks. He once again struggled with protection, something that has bothered the Chargers for a long time. Herbert also ran for 29 yards, and the offense pretty much revolved around him.

Raiders vs. Chargers Predictions

This is a long-time AFC West rivalry with plenty of tension involved. Right now, the Chargers are favorites, but the Raiders are coming into town having the momentum and without any pressure. Don’t be surprised to see the guests winning, yet we will take a more cautious approach and bet that LVR defends the spread.

Topics:

NFL

More Predictions

NFL Insight

NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread

Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]

Nikola Velickovic 3 min read

NFL Insight

NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow

NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]

Nikola Velickovic 2 min read

NFL Insight

Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina

Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]

Nikola Velickovic 2 min read

NFL Insight

Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly

Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]

Nikola Velickovic 2 min read

NFL Insight

Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland

Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]

Nikola Velickovic 2 min read