Expert prediction
NFL Week 12: Buffalo Bills vs Philadelphia Eagles Odds, and Picks (Nov 26)
Pick rationale
Analysis & key factors
- The Bills thrashed the Jets 6-32 on Sunday.
- The Eagles defeated the Chiefs 21-17 on Monday night.
- These teams have met just 14 times previously, with the Eagles leading the series 8-6-0.
The 6-5 Buffalo Bills take on the 9-1 Philadelphia Eagles in this thrilling week 12 matchup between two of this season’s Superbowl contenders.
How To Watch
- CBS
Game Preview
The Bills made light work of their week 11 matchup with the Jets, running out 6-32 winners. Sophomore wide receiver Khalil Shakir was the star of the show with 3 receptions for 115 yards and an 81 yard touchdown. Running back James Cook continued his steady progression with 17 carries for 73 yards as well as 3 catches for 29 yards and a score. Buffalo has been inconsistent through the first part of the season but as they head into the closing stretch it is clear to see that they will remain in the hunt for the big prize.
The Eagles fought back from a 7-17 deficit at halftime to beat the Chiefs 21-17 at the close of play. QB Jalen Hurts threw for just 150 yards on 14 completions but found the end zone twice from 12 rushing attempts. DeAndre Swift also added a score whilst rushing for 76 yards from his 12 carries. The Eagles offense have looked almost unstoppable at times this season, and their defense is once again the foundation that any Superbowl charge will be based upon.
Prediction
On any given day, either of these teams could come out of this matchup with a win. In games that are tough to predict, with a very close line, I tend to side with home field advantage. On that basis I’m going for an Eagles win, in what could be the game of the weekend.
NFL Picks
NFL
More Predictions
NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread
Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]
NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow
NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]
Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina
Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]
Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly
Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]
Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland
Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]