Skip to content

Expert prediction

NFL Week 12: Jacksonville Jaguars vs. Arizona Cardinals Preview, Odds, Picks (Nov 23)

  • Nikola Velickovic
  • Nov 18, 2025 at 11:52 AM EST

Pick rationale

Analysis & key factors

  • Jaguars vs. Cardinals odds favor Jacksonville at -145.
  • Total has gone OVER in 5 of the Cardinals’ last 6 games.
  • Jaguars are 1-4 ATS in the previous 5 games.

The Jags aren’t playing some particularly notable football, yet they are winning. On the other hand, the Cards have been sluggish, especially on the defensive side of the ball.

If you want more NFL odds and predictions, please follow this link.

How to Watch

  • When: Sunday, November 23, 4:25 pm ET
  • Where: State Farm Stadium, Glendale, Arizona
  • How to Watch: CBS

Jaguars vs. Cardinals Odds

TeamMoneylineSpreadTotals
Jaguars-145-2.547.5
Cardinals+125+2.547.5

Game Preview

The Jags won two of the last three events, with the defeat coming in Texas, in a game where they wasted a massive lead. Though trashing the Chargers 35-6 last weekend was quite the bounce back, as just a few expected to see such a huge win margin.

Trevor Lawrence didn’t have a notable passing game: 153 yards, one touchdown, one intercepted pass, plus one rushing score. Travis Etienne Jr. had 73 rushing yards and two touchdowns, while the other RB, Bhayshui Tuten, had 74 and one score. Jags limited the Chargers to only 42 running yards.

The Cardinals’ defense has been terrible over the past two weekends, allowing 83 points combined, while scoring 44. First, they lost to the Seahawks at home, 44-22, and then to the 49ers, 41-22.

Overall, they are 1-7 in the last 8 games, and it’s no wonder why Kyler Murray isn’t the starter anymore. Also, 5 of their last 6 games went OVER, and that’s something important for your NFL betting activities.

Jaguars vs. Cardinals Head to Head

Arizona leads 4-2 in the all-time series. The previous contest was in 2021 when they won in Jacksonville, 31-19.

Jaguars vs. Cardinals Predictions

This will be a tricky one because the Jags know to oscillate, yet they are the favorites here. Just in case, we would move away from predicting the winner and go with OVER 47.5 points. Arizona plays pretty much defenseless football, focusing on offense, which will create an environment for a high-scoring affair here.

Topics:

NFL

More Predictions

NFL Insight

NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread

Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]

Nikola Velickovic 3 min read

NFL Insight

NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow

NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]

Nikola Velickovic 2 min read

NFL Insight

Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina

Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]

Nikola Velickovic 2 min read

NFL Insight

Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly

Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]

Nikola Velickovic 2 min read

NFL Insight

Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland

Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]

Nikola Velickovic 2 min read