Expert prediction
NFL Week 12: Jacksonville Jaguars vs. Arizona Cardinals Preview, Odds, Picks (Nov 23)
- Nikola Velickovic
- Nov 18, 2025 at 11:52 AM EST
Pick rationale
Analysis & key factors
- Jaguars vs. Cardinals odds favor Jacksonville at -145.
- Total has gone OVER in 5 of the Cardinals’ last 6 games.
- Jaguars are 1-4 ATS in the previous 5 games.
The Jags aren’t playing some particularly notable football, yet they are winning. On the other hand, the Cards have been sluggish, especially on the defensive side of the ball.
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How to Watch
- When: Sunday, November 23, 4:25 pm ET
- Where: State Farm Stadium, Glendale, Arizona
- How to Watch: CBS
Jaguars vs. Cardinals Odds
Game Preview
The Jags won two of the last three events, with the defeat coming in Texas, in a game where they wasted a massive lead. Though trashing the Chargers 35-6 last weekend was quite the bounce back, as just a few expected to see such a huge win margin.
Trevor Lawrence didn’t have a notable passing game: 153 yards, one touchdown, one intercepted pass, plus one rushing score. Travis Etienne Jr. had 73 rushing yards and two touchdowns, while the other RB, Bhayshui Tuten, had 74 and one score. Jags limited the Chargers to only 42 running yards.
Trevor Lawrence already has the most rushing TDs by a QB in #Jaguars franchise history.
— Daniel Griffis (@DanDGriffis) November 16, 2025
He adds to it, 19 career rushing TDs.
pic.twitter.com/fF5Ba3WeRD
The Cardinals’ defense has been terrible over the past two weekends, allowing 83 points combined, while scoring 44. First, they lost to the Seahawks at home, 44-22, and then to the 49ers, 41-22.
Overall, they are 1-7 in the last 8 games, and it’s no wonder why Kyler Murray isn’t the starter anymore. Also, 5 of their last 6 games went OVER, and that’s something important for your NFL betting activities.
Jaguars vs. Cardinals Head to Head
Arizona leads 4-2 in the all-time series. The previous contest was in 2021 when they won in Jacksonville, 31-19.
Jaguars vs. Cardinals Predictions
This will be a tricky one because the Jags know to oscillate, yet they are the favorites here. Just in case, we would move away from predicting the winner and go with OVER 47.5 points. Arizona plays pretty much defenseless football, focusing on offense, which will create an environment for a high-scoring affair here.
- Free NFL Picks: Over 47.5 points
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