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Expert prediction

NFL Week 13: New York Giants vs. New England Patriots Preview, Odds, Picks (Dec 1)

  • Nikola Velickovic
  • Nov 28, 2025 at 9:38 AM EST

Pick rationale

Analysis & key factors

  • Giants vs. Patriots odds heavily favor New England at -400.
  • The Patriots lead the AFC and hav 9 wins in a row.
  • The total went OVER in 6 of the Giants’ last 7 games.

The New York Giants head to Foxborough to meet with the AFC leaders, the New England Patriots.

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How to Watch

  • When: Monday, December 1, 8:15 pm ET
  • Where: Gillette Stadium, Foxborough, Massachusetts
  • How to Watch: ESPN

Giants vs. Patriots Odds

TeamMoneylineSpreadTotals
Giants+300+746.5
Patriots-400-746.5

Game Preview

The Giants really didn’t have any luck this year. Injuries snapped what could have been a very interesting and promising season for the franchise from the Big Apple. Though, QB Jaxson Dart is set to go, and we’ll see if the Giants use him in this event.

Defense is a better part of the team. LB Brian Burns has 13 sacks, and if it weren’t for Myles Garrett, this guy would’ve been the top contender for the DPOY award.

The Patriots have their candidate for one award, only it’s the NFL MVP. His name is Drake Maye. This guy currently has 3,130 passing yards, 21 touchdown passes, and 6 interceptions. And he makes big plays.

On the other hand is the defense, probably the most well-rounded in the league. There are no superstars nor “special individuals,” but it plays well. Pats allow 18.8 points per game, No.4 in the league, and limit the rivals to 87.7 rushing yards, which is the second-best—enough said.

Giants vs. Patriots Head to Head

This rivalry saw 14 matches, and the series is tied. However, the Giants beat the Pats twice in the Super Bowl games, at XLII and XLVI.

Giants vs. Patriots Predictions

New York Giants, with or without Dart, will have a hard time getting out of Foxborough undefeated. Why? Because they play against one of the best teams in the league, who has the quality to hurt them in so many ways. Starting with the defense. So it’s the Patriots -7.

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