Expert prediction
NFL Week 14: Cincinnati Bengals vs. Buffalo Bills Preview, Odds, Picks (Dec 7)
- Nikola Velickovic
- Dec 1, 2025 at 5:07 AM EST
Pick rationale
Analysis & key factors
- Bengals vs. Bills odds favor Buffalo at -280.
- The TOTAL for this game is 51.5 points.
- Joe Burrow is back, and the Bengals hope for a late playoff push.
Everything is much easier with Joe Burrow on board. After winning in Baltimore, the Bengals hope for another upset, only now in Buffalo.
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How to Watch
- When: Sunday, December 7, 1 pm ET
- Where: Highmark Stadium, Orchard Park, New York
- How to Watch: FOX
Bengals vs. Bills Odds
Game Preview
The Bengals beat the Ravens on the road, 32-14, which was the upset of the round. Though, when you have Joe Burrow, nothing is impossible. Yet here, it wasn’t about Burrow, but the defensive effort, with the Bengals forcing 5 turnovers, three on Lamar.
Burrow didn’t have some ultra-big night, throwing for 261 yards, two touchdowns and completing only 24 of his 46 passes. Ja’Marr Chase had 110 receiving yards in 7 receptions, while TD catches had Andrei Iosivas and Tanner Hudson.
I WANT TO RUN THROUGH A BRICK WALL FOR JOE BURROW
— SleeperBengals (@SleeperBengals) November 28, 2025
pic.twitter.com/bwCcA8Pg93
The Bills were ruthless in Pittsburgh, beating the Steelers, 26-7. There wasn’t the slightest chance for the hosts to avoid a defeat, because Allen and the boys played hard and merciless football.
Buffalo had 249 rushing yards, with James Cook posting 144 on 32 snaps. He also had 33 receiving yards and was the man of the match. Allen ran for 38 yards and a TD, while posting 123 passing yards for an interception and a TD.
Bengals vs. Bills Head to Head
There were 34 matches so far, with the record tied at 17-17. The Bengals won the last two games, one in the 2022 playoffs and the other in the 2023 season.
Bengals vs. Bills Predictions
The TOTAL is set at 51.5 points here, and we pick OVER. No matter the weather, with Burrow, the Bengals are an efficient bunch, and the same goes for the Bills, who are playing way better at home than on the road.
- Free NFL Picks: Over 51.5 points
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