Skip to content

Expert prediction

NFL Week 16: Jacksonville Jaguars vs. Denver Broncos Preview, Odds, Picks (Dec 21)

  • Nikola Velickovic
  • Dec 17, 2025 at 5:58 AM EST

Pick rationale

Analysis & key factors

  • Jaguars vs. Broncos odds favor Denver at -165.
  • The Jacksonville Jaguars have 5 wins in a row.
  • Denver Broncos won 12 straight matches.

Apparently, the Broncos are the best team in the league, but they host one more in-form team, the Jaguars.

If you want more NFL odds and predictions, please follow this link.

How to Watch

  • When: Sunday, December 21, 4:05 pm ET
  • Where: Mile High, Denver, Colorado
  • How to Watch: FOX

Jaguars vs. Broncos Odds

TeamMoneylineSpreadTotals
Jaguars+135+345.5
Broncos-165-345.5

Game Preview

Jacksonville looks good, having won 5 of its previous games and scoring at least 25 points in each game. Trevor Lawrence looks consistent enough and plays at a Pro Bowl level.

The defense needs to be credited as well, especially the run defense, which ranks top in the NFL, allowing opponents 86.3 yards per game. If they keep playing like this, the Jags could do well in the playoffs.

The Broncos are possibly the best team in the NFL. Last weekend, they defeated the Packers at home, 34-26, with Bo Nix proving that he can deliver in high-scoring events.

Nix threw for 4 touchdown passes, 302 passing yards, and was without an interception. He also didn’t suffer a single sack, and that’s something for which the O-Line needs to be praised.

Jaguars vs. Broncos Head to Head

The Broncos lead the series 8-7, having won 4 of the last 5 games.

Jaguars vs. Broncos Predictions

Jacksonville’s run defense will be heavily tested here, and if they succeed in slowing down the Broncos, this team has a chance to win. Meanwhile, the Broncos’ defense is one of the best in the league, so our suggestion here is to bet the UNDER 45.5 points.

Topics:

NFL

More Predictions

NFL Insight

NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread

Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]

Nikola Velickovic 3 min read

NFL Insight

NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow

NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]

Nikola Velickovic 2 min read

NFL Insight

Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina

Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]

Nikola Velickovic 2 min read

NFL Insight

Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly

Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]

Nikola Velickovic 2 min read

NFL Insight

Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland

Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]

Nikola Velickovic 2 min read