Expert prediction
NFL Week 16: Jacksonville Jaguars vs. Denver Broncos Preview, Odds, Picks (Dec 21)
- Nikola Velickovic
- Dec 17, 2025 at 5:58 AM EST
Pick rationale
Analysis & key factors
- Jaguars vs. Broncos odds favor Denver at -165.
- The Jacksonville Jaguars have 5 wins in a row.
- Denver Broncos won 12 straight matches.
Apparently, the Broncos are the best team in the league, but they host one more in-form team, the Jaguars.
If you want more NFL odds and predictions, please follow this link.
How to Watch
- When: Sunday, December 21, 4:05 pm ET
- Where: Mile High, Denver, Colorado
- How to Watch: FOX
Jaguars vs. Broncos Odds
Game Preview
Jacksonville looks good, having won 5 of its previous games and scoring at least 25 points in each game. Trevor Lawrence looks consistent enough and plays at a Pro Bowl level.
The defense needs to be credited as well, especially the run defense, which ranks top in the NFL, allowing opponents 86.3 yards per game. If they keep playing like this, the Jags could do well in the playoffs.
PS2 ✍️ mural poster!
— Denver Broncos (@Broncos) December 15, 2025
RT for your chance to win & #ProBowlVote for @PatSurtainll pic.twitter.com/q5NBrF1dHv
The Broncos are possibly the best team in the NFL. Last weekend, they defeated the Packers at home, 34-26, with Bo Nix proving that he can deliver in high-scoring events.
Nix threw for 4 touchdown passes, 302 passing yards, and was without an interception. He also didn’t suffer a single sack, and that’s something for which the O-Line needs to be praised.
Jaguars vs. Broncos Head to Head
The Broncos lead the series 8-7, having won 4 of the last 5 games.
Jaguars vs. Broncos Predictions
Jacksonville’s run defense will be heavily tested here, and if they succeed in slowing down the Broncos, this team has a chance to win. Meanwhile, the Broncos’ defense is one of the best in the league, so our suggestion here is to bet the UNDER 45.5 points.
- Free NFL Picks: Under 45.5 points
NFL
More Predictions
NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread
Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]
NNikola Velickovic 3 min read
NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow
NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]
NNikola Velickovic 2 min read
Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina
Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]
NNikola Velickovic 2 min read
Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly
Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]
NNikola Velickovic 2 min read
Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland
Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]
NNikola Velickovic 2 min read