Skip to content

Expert prediction

NFL Week 16: Kansas City Chiefs vs. Tennessee Titans Preview, Odds, Picks (Dec 21)

  • Nikola Velickovic
  • Dec 16, 2025 at 5:27 PM EST

Pick rationale

Analysis & key factors

  • Chiefs vs. Titans odds favor Kansas City at -200.
  • Patrick Mahomes tore his ACL and LCL and is out for a long time.
  • In 6 of the last 8 games, the Titans played, the TOTAL went OVER.

Patrick Mahomes is injured, and the Chiefs are out of the playoff zone. That’s the summary of this game. As for the Titans, they are 2-12 this season. That’ summarizes everything one should know about them.

If you want more NFL odds and predictions, please follow this link.

How to Watch

  • When: Sunday, December 21, 1 pm ET
  • Where: Nissan Stadium, Nasville, Tennessee
  • How to Watch: CBS

Chiefs vs. Titans Odds

TeamMoneylineSpreadTotals
Chiefs-200-3.537.5
Titans +165+3.537.5

Game Preview

There couldn’t be a worse scenario for the Chiefs this weekend than to suffer a loss and to lose Patrick Mahomes long-term. He tore both the ACL and the LCL, which is a huge bust for the team and its future.

Gardner Minshew will replace Mahomes, and from what we saw against the Chargers, when he threw an interception that sealed the game, the backup QB needs to be much better. Though, there won’t be any pressure on him now, because the team can’t reach the playoffs.

The same goes for the Titans, who are 2-12 this season and are in a rebuild. All eyes are on Cam Ward, the No.1 pick from this year’s draft, and his progress.

Tennessee comes back home after a two-game stretch on the road. They would beat the Browns in Cleveland, 31-29, and then lost to the Niners in San Francisco, 37-24. Ward was good at Levi’s Stadium, throwing for 170 passing yards and two touchdowns. He was neither sacked nor picked.

Chiefs vs. Titans Head to Head

These two teams have met 56 times, and the Chiefs lead 31-25. The last meeting was in 2022, when KC won after OT, 20-17 at home.

Chiefs vs. Titans Predictions

The spread on the Chiefs is 3.5 points, and they are good enough to cover that, no matter Mahomes’ absence. Sure, his injury is a disaster, but the Chiefs won’t become the Raiders or the Titans right away.

Topics:

NFL

More Predictions

NFL Insight

NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread

Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]

Nikola Velickovic 3 min read

NFL Insight

NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow

NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]

Nikola Velickovic 2 min read

NFL Insight

Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina

Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]

Nikola Velickovic 2 min read

NFL Insight

Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly

Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]

Nikola Velickovic 2 min read

NFL Insight

Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland

Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]

Nikola Velickovic 2 min read