Expert prediction
NFL Week 17: Chicago Bears vs. San Francisco 49ers Preview, Odds, Picks (Dec 28)
- Nikola Velickovic
- Dec 25, 2025 at 4:28 AM EST
Pick rationale
Analysis & key factors
- Bears vs. 49ers odds favor San Francisco by 3 points.
- San Francisco plays superbly despite all the injuries.
- Bears are 7-1 in the last 8 matches.
This is the game that will have massive implications on the NFL standings. Both teams are after top seeds in their divisions, and can also reach the No.1 seed in the NFC.
If you want more NFL odds and predictions, please follow this link.
How to Watch
- When: Sunday, December 28, 8:20 pm ET
- Where: Levi’s Stadium, San Francisco, California
- How to Watch: NBC, Peacock
Bears vs. 49ers Odds
Game Preview
The Chicago Bears had a miraculous comeback against the Packers, winning 22-16, and taking over the top spot in the division against their archrivals. Caleb Williams danced when it mattered the most, throwing for 250 passing yards and two touchdowns.
Running backs were solid, providing 150 yards on the ground, and just to add that the Bears are No.2 in the league in rushing, with 151.7 yards per game.
#49ers QB Brock Purdy has been named the NFC Offensive player of the week 🔥 pic.twitter.com/tfIE7GBO1d
— OurSF49ers (@OurSf49ers) December 24, 2025
The 49ers have had unbelievable injury problems this year, but they are among the best teams in the NFC. Kyle Shanahan’s brilliant mind shines again. The Niners have 5 wins in a row, and are very offensive-minded.
Five of the last 7 games played went OVER, and, just to remember, in all five of their previous wins, San Francisco also covered the spread, which tells us enough about their confidence.
Bears vs. 49ers Head to Head
After 70 encounters, the Niners have a slight edge, 36-33-1. Their previous game was last year, when the 49ers beat the Bears, 38-13 at Levi’s.
Bears vs. 49ers Predictions
The Chicago Bears have been on fire, that’s a fact, but we are more than sure that the 49ers are something they haven’t encountered in the recent past. They’ve beaten the Packers, but without Parsons and Love, and even that was lucky. That’s why we pick the hosts to triumph and cover the spread.
- Free NFL Picks: 49ers -3
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