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Expert prediction

NFL Week 2: Rams vs. Titans Preview, Odds, Picks (Sep 14)

  • Nikola Velickovic
  • Sep 9, 2025 at 7:27 AM EDT

Pick rationale

Analysis & key factors

  • Rams vs. Titans game total is set at 41.5 points.
  • The Los Angeles Rams are 6.5-point favorites.
  • Cam Ward was sacked 6 times against the Broncos.

LA Rams beat the Texans in Week 1, while the Titans, that is, Cam Ward, experienced first-hand what it’s like to play at Mile High.

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How to Watch

  • When: Sunday, September 14, 1 pm ET
  • Where: Nissan Stadium, Nashville, Tennessee
  • How to Watch: CBS

Rams vs. Texans Odds

TeamMoneylineSpreadTotals
Rams-260-5.541.5
Bills+215+5.541.5

Game Preview

Matt Stafford not only led the Rams to a 14-9 win in Houston vs. the Texans, but also eclipsed the 60,000-passing yards limit. He became only the 10th QB in history to do that and the second-fastest.

The Texans’ powerful defense struck both WRs – Davante Adams and Puka Nacua, yet the two eventually ended the night well. Nacua had 130 yards on 10 catches. Runner Kyreen Williams had 66 yards on the ground and one score.

Cam Ward was sacked 6 times at the Mile High, losing 50 yards. His stats were pretty modest: 12-for-28 for 112 passing yards, no runs, and one fumble. Though, to be honest, much more experienced veterans didn’t do better in Colorado.

Tennessee’s defense did produce solid pressure on Bo Nix, even though they produced just one sack, coming from Jeffery Simmons, who also had 4 QB hits. The 28-year-old DT is the only one worth mentioning from the Titans’ defense.

Rams vs. Titans Head to Head

The Rams lead the head-to-head against the Titans, 8-6. Though, the Titans won the previous event, back in 2021, 28-16 in LA.

Rams vs. Titans Predictions

The Rams’ offense is way too strong for the Titans, while on the other hand, Cam Ward is still trying to find himself, and he presents an easy target for Jared Verse and the crew. We’re going with the Rams in this one.

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