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Expert prediction

NFL Week 3: Broncos vs. Chargers Preview, Odds, Picks (Sep 21)

  • Nikola Velickovic
  • Sep 16, 2025 at 6:19 PM EDT

Pick rationale

Analysis & key factors

  • Broncos vs. Chargers is a fierce AFC West rivalry.
  • Justin Herbert has 5 touchdowns this season.
  • The Broncos lost to the Colts on the road, 29-28, in Week 2.

This game might have a huge impact on the AFC West standings, because the Chiefs won’t be the absolute ruler of this assembly anymore.

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How to Watch

  • When: Sunday, September 21, 4:05 pm ET
  • Where: SoFi Stadium, Los Angeles, California
  • How to Watch: CBS

Broncos vs. Chargers Odds

TeamMoneylineSpreadTotals
Broncos+125+2.545.5
Chargers-145-2.545.5

Game Preview

Denver was stopped by the Colts on the road in a thrilling game that ended 29-28. Spencer Shrader converted a 45-yard field goal as time expired to sink the Broncos, who had held a 28-20 lead early in the third quarter.

The Broncos’ defense, one of the best in the NFL, had a lousy night, recording just one sack and allowing 473 yards from scrimmage. Now that’s a lot for Denver’s standards. Meanwhile, Bo Nix threw for 206 yards and 3 TDs with an interception.

LAC stifled the Raiders in another AFC West clash, 20-9. Last year’s top NFL defense showed what it’s all about, forcing Geno Smith to throw three picks.

As for Herbert, he had 242 passing yards for 2 TDs, and he ran 31 yards. Quentin Johnston and Keenan Allen were his targets, both having a score, and they posted 71 and 61 receiving yards, respectively.  

Broncos vs. Chargers Head to Head

The Denver Broncos lead 73-57 in the all-time series. Plus, there is one tie involved. Last year, the Chargers won both matches, 23-16 at the Mile High and 34-27 at home.

Broncos vs. Chargers Predictions

This will be one hell of a game for those who love good defense. The over/under line is set at 45.5 points and we are definitely for under.

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