Skip to content

Expert prediction

NFL Week 3: Chiefs vs. Giants Preview, Odds, Picks (Sep 21)

  • Nikola Velickovic
  • Sep 17, 2025 at 5:24 AM EDT

Pick rationale

Analysis & key factors

  • Chiefs vs. Giants odds favor Kansas City at -290.
  • Giants lost in Dallas following an OT, 40-37.
  • Cameras caught Travis Kelce frustrated over Mahomes.

During the game against the Eagles, the cameras caught Travis Kelce cursing and frustrated due to Patrick Mahomes’ actions on the field. Is this the beginning of a breakup?  

If you want more NFL odds and predictions, please follow this link.

How to Watch

  • When: Sunday, September 21, 8:20 pm ET
  • Where: MetLife Stadium, East Rutherford, New Jersey
  • How to Watch: NBC

Chiefs vs. Giants Odds

TeamMoneylineSpreadTotals
Chiefs-290-6.545.5
Giants+240+6.545.5

Game Preview

The Chiefs are 0-2, and that’s something alarming for the 3-time Super Bowl champs. But what is even more problematic is the mentioned footage. That’s something nobody expected. Some are saying it’s because of the tension on the field.

Anyhow, the Chiefs lost to the Eagles at home, 20-17. The difference in the field was one turnover, Mahomes’ interception. Overall, Kansas City didn’t play badly; they just happened to have a Super Bowl champ across the field.

After losing to the Commanders, 21-6, the Giants went toe-to-toe with the Cowboys in Arlington, falling down following an OT, 40-37. They played well, we have to give them credit, but in the end, small details prevailed on Dallas’ side.

Russell Wilson reminded us of his old self, having a couple of big plays and posting 450 passing yards for 3 touchdowns. WRs Malik Nabers had 167 receiving yards for 2 scores, and Wan’Dale Robinson added 142 receiving yards for a touchdown.

Chiefs vs. Giants Head to Head

Giants lead the series 11-4, while the last game played in KC ended with the hosts’ win 20-17.

Chiefs vs. Giants Predictions

Kansas City lost both of its matches closely, and these results are not a reflection of its true power. This team is still a Super Bowl contender, and they will show that against the Giants, who are going to oscillate a lot throughout the season.

Topics:

NFL

More Predictions

NFL Insight

NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread

Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]

Nikola Velickovic 3 min read

NFL Insight

NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow

NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]

Nikola Velickovic 2 min read

NFL Insight

Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina

Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]

Nikola Velickovic 2 min read

NFL Insight

Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly

Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]

Nikola Velickovic 2 min read

NFL Insight

Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland

Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]

Nikola Velickovic 2 min read